Radon-222 and its parent Radium-226 are naturally occurring radioactive decay products of Uranium-238. The US Environmental Protection Agency (USEPA) attributes about 10 percent of lung cancer cases that is `around 21,000 deaths per year’ in the United States, caused due to indoor radon. The USEPA has categorized Ohio as a Zone 1 state (i.e. the average indoor radon screening level greater than 4 picocuries per liter). In order to implement preventive measures, it is necessary to know radon concentration levels in all the zip codes of a geographic area. However, it is not possible to survey all the zip codes, owing to reasons such as inapproachability. In such places where radon data are unavailable, several interpolation techniques are used to estimate the radon concentrations. This thesis presents a comparison between recently developed interpolation techniques to new techniques such as Support Vector Regression (SVR), and Random Forest Regression (RFR). Recently developed interpolation techniques include Artificial Neural Network (ANN), Knowledge Based Neural Networks (KBNN), Correction-Based Artificial Neural Networks (CBNN) and the conventional interpolation techniques such as Kriging, Local Polynomial Interpolation (LPI), Global Polynomial Interpolation (GPI) and Radial Basis Function (RBF) using the K-fold cross validation method.