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Modeling End-to-End Annealing of Intermediate Filaments
Pritchard, Adaleigh Elizabeth

2014, Master of Mathematical Sciences, Ohio State University, Mathematics.
Intermediate filaments, which make up part of the cytoskeleton, play an important role in providing cells with structural stability [8,3]. The mechanism by which intermediate filaments are able to grow and form networks is, therefore, of interest. Previous mathematical models fit in vitro length distribution data for vimentin (a type of intermediate filament found in cells of mesenchymal origin) only by choosing kinetic rates from obtained from several distinct expressions which arise from various assumptions of the mechanical properties of the filaments. My goal is to improve on existing mathematical models of end-to-end annealing by determining a single underlying expression by which kinetic rates can be determined. Filaments are modeled as semiflexible linear polymers with a probability of annealing which has a decreasing dependence on the length of the filaments. With this approach, the model fit experimental in vitro length distribution data for vimentin [21].
Chuan Xue, PhD (Advisor)
Anthony Brown, PhD (Advisor)
Adriana Dawes, PhD (Committee Member)
41 p.

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Pritchard, A. (2014). Modeling End-to-End Annealing of Intermediate Filaments. (Electronic Thesis or Dissertation). Retrieved from https://etd.ohiolink.edu/

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Pritchard, Adaleigh. "Modeling End-to-End Annealing of Intermediate Filaments." Electronic Thesis or Dissertation. Ohio State University, 2014. OhioLINK Electronic Theses and Dissertations Center. 23 Nov 2017.

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Pritchard, Adaleigh "Modeling End-to-End Annealing of Intermediate Filaments." Electronic Thesis or Dissertation. Ohio State University, 2014. https://etd.ohiolink.edu/

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