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Theoretical Investigation of Cell Polarity Initiation in the Early C. Elegans Embryo
Kravtsova, Natalia

2014, Master of Mathematical Sciences, Ohio State University, Mathematics.
Polarization is the process by which chemical species are unequally distributed throughout the cell creating biochemically distinct domains. In this study, mathematical modeling is used to theoretically determine what types of initial stimuli are able to initiate successful polarization.
The model consist of five reaction-diffusion-advection partial differential equations for the main players in polarization process: ParA proteins (three forms), ParP proteins, and actomyosin protein complex. Equations are solved by method of lines, and data fitting is performed by linear and non-linear optimization methods (implemented in Matlab).
Simulations of the model show that biochemical stimulus results in polarization of the embryo, while purely mechanical stimulus does not. In addition, regulation of actomyosin by inhibition from ParP and enhancement from ParA are studied, and it is found that inhibition from ParP plays more significant role in actomyosin regulation. Theoretical findings of this study suggest ways to direct biological experiments.
Adriana Dawes, Dr. (Advisor)
Helen Chamberlin, Dr. (Advisor)
40 p.

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Kravtsova, N. (2014). Theoretical Investigation of Cell Polarity Initiation in the Early C. Elegans Embryo. (Electronic Thesis or Dissertation). Retrieved from https://etd.ohiolink.edu/

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Kravtsova, Natalia. "Theoretical Investigation of Cell Polarity Initiation in the Early C. Elegans Embryo." Electronic Thesis or Dissertation. Ohio State University, 2014. OhioLINK Electronic Theses and Dissertations Center. 21 Sep 2017.

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Kravtsova, Natalia "Theoretical Investigation of Cell Polarity Initiation in the Early C. Elegans Embryo." Electronic Thesis or Dissertation. Ohio State University, 2014. https://etd.ohiolink.edu/

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