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Quantification of Pharmacokinetics in Small Animals with Molecular Imaging and Compartment Modeling Analysis
Fang, Yu-Hua

2009, Doctor of Philosophy, Case Western Reserve University, Biomedical Engineering.
In the recent years molecular imaging has become an important tool in biomedical research. To quantify physiology from image data, compartment modeling has been shown to be useful by analyzing the pharmacokinetics from molecular images. However, some challenges still exist and limit the application of compartment modeling in a routine basis. Methods to resolve some of the existing challenges are proposed and validated in this thesis. First, non-invasive methods are developed to measure the input functions required in compartment modeling and parameter estimation for positron-emission tomography (PET) and dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) studies. Methods for image-derived input functions are developed and validated against the reference input functions. Second, a software environment is established to integrate functions that handle image analysis and modeling analysis based on COmpartment Model Kinetic Analysis Tool (COMKAT). Methods to enhance speed and interface for COMKAT have been implemented as described in this thesis. With the methods and software developed in this thesis, researchers can quantify in vivo pharmacokinetics with molecular imaging methods to measure the physiology and metabolism non-invasively in a routine basis.
Raymond Muzic, PhD (Advisor)
Xin Yu, PhD (Committee Chair)
Gerald Saidel, PhD (Committee Member)
Peter Faulhaber, MD (Committee Member)
196 p.

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Fang, Y. (2009). Quantification of Pharmacokinetics in Small Animals with Molecular Imaging and Compartment Modeling Analysis. (Electronic Thesis or Dissertation). Retrieved from https://etd.ohiolink.edu/

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Fang, Yu-Hua. "Quantification of Pharmacokinetics in Small Animals with Molecular Imaging and Compartment Modeling Analysis." Electronic Thesis or Dissertation. Case Western Reserve University, 2009. OhioLINK Electronic Theses and Dissertations Center. 10 Dec 2017.

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Fang, Yu-Hua "Quantification of Pharmacokinetics in Small Animals with Molecular Imaging and Compartment Modeling Analysis." Electronic Thesis or Dissertation. Case Western Reserve University, 2009. https://etd.ohiolink.edu/

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