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Oxygen Sensing Electrospun Nanofibers for Biological Applications
Presley, Kayla Fay

2018, Doctor of Philosophy, Ohio State University, Materials Science and Engineering.
Incorporation of luminescent oxygen-sensitive molecules into electrospun polymeric nanofibers can create a sensor with linear Stern-Volmer behavior and a rapid response time. This overcomes several issues associated with traditional polymer film-based sensors. Nevertheless, disadvantages remain that could limit use in biological applications: photobleaching, excitation wavelengths that poorly penetrate tissue and difficulties associated with delivery. This work attempts to address each of these issues. Systematic studies on long-term photobleaching have examined the effect of specific parameters (i.e., electrospinning solvent, porphyrin content) on decreases in sensor brightness and oxygen sensitivity. While ultraviolet and visible excitation wavelengths exhibit poor tissue penetration, near-infrared (NIR) light much more easily penetrates tissue due to decreased scattering and absorbance by tissue chromophores. The ability to achieve NIR-activated oxygen sensing in electrospun bilayer and core-shell nanofibers has been demonstrated by using upconverting particles to locally stimulate oxygen-sensitive molecules. Finally, concerns associated with delivery have been addressed by utilizing the same sensing components in the form of polymeric core-shell particles.
John Lannutti (Advisor)
Heather Powell (Committee Member)
Jinwoo Hwang (Committee Member)
241 p.

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Presley, K. (2018). Oxygen Sensing Electrospun Nanofibers for Biological Applications. (Electronic Thesis or Dissertation). Retrieved from https://etd.ohiolink.edu/

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Presley, Kayla. "Oxygen Sensing Electrospun Nanofibers for Biological Applications." Electronic Thesis or Dissertation. Ohio State University, 2018. OhioLINK Electronic Theses and Dissertations Center. 22 Oct 2018.

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Presley, Kayla "Oxygen Sensing Electrospun Nanofibers for Biological Applications." Electronic Thesis or Dissertation. Ohio State University, 2018. https://etd.ohiolink.edu/

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Full text release has been delayed at the author's request until August 06, 2021