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Evaluation of the Role of Cross-links on Microtubule Mechanics Using a Co-rotational Finite Element Simulation
Abdollahi Nohouji, Neda

2018, Master of Science in Mechanical Engineering, Cleveland State University, Washkewicz College of Engineering.
Traumatic injuries and neurodengerative disease are two primary and debilitating causes of cell damage and death in the nervous system. Understanding the mechanobiological behavior of the neuron, and in particular the influence of the mechanical environment on microtubules, is integral to the prevention and treatment of many of these conditions. Within the axon, microtubules are the primary filament that provide structural support and cargo transport. The central nervous system has been a primary focus, where axonal microtubules have been studied for both traumatic brain injury [1] and many neurodegenerative diseases. Beyond the many invaluable experimental tools, modeling is a complementary tool to study the mechanics of a “bundle” of microtubules. Previous work adopted a discrete element formulation [1], though it is unclear how these assumed dynamic simulations affect modeling capabilities. A finite element (FE) based approach offers the possibility to model potentially important bending behavior (i.e. beam elements), may result in more efficient simulations, and when implemented with a co-rotational formulation [2] can account for large deformations. Hence, the goal of this work was to 1. verify implementation of a co-rotational formulation for traditional beam and truss finite elements and 2. apply the framework to predict the mechanical response of a typical microtubule bundle.
Jason Halloran (Advisor)
Richter Hanz (Committee Member)
Kothapalli Chandra (Committee Member)
73 p.

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Abdollahi Nohouji, N. (2018). Evaluation of the Role of Cross-links on Microtubule Mechanics Using a Co-rotational Finite Element Simulation. (Electronic Thesis or Dissertation). Retrieved from https://etd.ohiolink.edu/

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Abdollahi Nohouji, Neda. "Evaluation of the Role of Cross-links on Microtubule Mechanics Using a Co-rotational Finite Element Simulation." Electronic Thesis or Dissertation. Cleveland State University, 2018. OhioLINK Electronic Theses and Dissertations Center. 15 Oct 2018.

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Abdollahi Nohouji, Neda "Evaluation of the Role of Cross-links on Microtubule Mechanics Using a Co-rotational Finite Element Simulation." Electronic Thesis or Dissertation. Cleveland State University, 2018. https://etd.ohiolink.edu/

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Full text release has been delayed at the author's request until December 13, 2018