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In vitro assessment of the effects of valvular stenosis on aorta hemodynamics and left ventricular function
Madan, Ashish

2018, Master of Science in Mechanical Engineering (MSME), Wright State University, Mechanical Engineering.
Calcific aortic stenosis (CAS) is the most common valvular heart disease and is associated with aortopathy and ventricular dysfunction. Hemodynamic alterations due CAS could affect the aorta lining (endothelium), that is in direct contact with the blood, triggering adverse biological responses that may possibly cause aortic dilation and dissection. Also, CAS could impose excessive ventricular load leading to ventricular wall thickening, thus putting an individual at a higher risk of heart attack or stroke. These pathophysiological effects of CAS are highly dependent on the degree of calcification. However, the impact of CAS development on aorta flow and left ventricular workload remains largely unknown. Hence the objective of this study is to measure experimentally the effect of CAS on aorta hemodynamics using particle image velocimetry; and left ventricular function in terms of left ventricular work, at different stages of calcification. This study will provide insights on aorta flow abnormalities and left ventricular overload, due CAS, which can be linked to aortopathy and heart failure.
Philippe Sucosky, Ph.D., F.A.H.A. (Advisor)
George Huang, Ph.D. (Committee Member)
Zifeng Yang, Ph.D. (Committee Member)
106 p.

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Madan, A. (2018). In vitro assessment of the effects of valvular stenosis on aorta hemodynamics and left ventricular function. (Electronic Thesis or Dissertation). Retrieved from https://etd.ohiolink.edu/

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Madan, Ashish. "In vitro assessment of the effects of valvular stenosis on aorta hemodynamics and left ventricular function." Electronic Thesis or Dissertation. Wright State University, 2018. OhioLINK Electronic Theses and Dissertations Center. 19 Oct 2018.

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Madan, Ashish "In vitro assessment of the effects of valvular stenosis on aorta hemodynamics and left ventricular function." Electronic Thesis or Dissertation. Wright State University, 2018. https://etd.ohiolink.edu/

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