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A Mathematical Model of Cytokinetic Morphogenesis
Anderson, Kerri-Ann

2015, Master of Mathematical Sciences, Ohio State University, Mathematics.
Cytokinesis occurs through coordinated biochemical processes that result in biophysical stresses that act on the cytoskeleton. In order to uncover the physical mechanisms responsible for the cytokinetic behavioral differences between normal and abnormal cells, we use computational methods to simulate the effects of varying these physical mechanisms; our methods are applied to both deterministic and stochastic models. Particularly in non-adhesive conditions, it has been observed that Myosin II Contractile Force is the major driving force of furrow ingression. Modification of the maximum myosin stress parameter, the myosin distribution and cell elasticity achieved results that coincide with other findings and biological inferences about cell behavior. The model presented in this report provides a preliminary basis for future quantitative identification of abnormal cells, and the identification of possible cancer therapeutic targets. Via this model we are able to gain further understanding of the bio-mechanical properties of cells and their effects on cytokinesis.
Ching-Shan Chou, PhD (Advisor)
Adriana Dawes, PhD (Committee Member)
39 p.

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Anderson, K. (2015). A Mathematical Model of Cytokinetic Morphogenesis. (Electronic Thesis or Dissertation). Retrieved from https://etd.ohiolink.edu/

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Anderson, Kerri-Ann. "A Mathematical Model of Cytokinetic Morphogenesis." Electronic Thesis or Dissertation. Ohio State University, 2015. OhioLINK Electronic Theses and Dissertations Center. 21 Nov 2017.

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Anderson, Kerri-Ann "A Mathematical Model of Cytokinetic Morphogenesis." Electronic Thesis or Dissertation. Ohio State University, 2015. https://etd.ohiolink.edu/

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