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Mathematical Model of the Combined Effect of IL-6, TGF-beta and TNF-alpha on Pancreatic Stellate Cell Activation
Feldges, Robert

2015, Master of Mathematical Sciences, Ohio State University, Mathematics.
Chronic pancreatitis is a long-term inflammatory disease of the pancreas that renders the pancreas unable to produce enzymes in the amounts needed for the body. Playing a crucial role in the genesis of the disease are the pancreatic stellate cells (PSCs) found in the peracinar region of the organ. Their activation is enhanced by tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6), cytokines released by macrophages drawn into the pancress through inflamed endothelial cells. The PSCS release additional cytokines, including transforming growth factor beta (TGF-β. Together these soluble factors likely have an effect on the activation of PSC, their proliferation rate and subsequent secretion of cytokines into the pancreatic microenvironment. Using data obtained from a collaborating research laboratory and data found in the literature, I have formulated several differential equations linking the concentrations of these cytokines. In addition, I have formulated one differential equation analyzing the effect of the drug somatostatin on cytokine levels. These equations deserve evaluation for future potential use in diagnosing the course of pancreatic cancer. They may also be useful for the study of interdependency of more cytokines and more drugs on the disease process.
Avner Friedman, Dr. (Advisor)
Gregory Lesinski, Dr. (Committee Member)
25 p.

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Feldges, R. (2015). Mathematical Model of the Combined Effect of IL-6, TGF-beta and TNF-alpha on Pancreatic Stellate Cell Activation. (Electronic Thesis or Dissertation). Retrieved from https://etd.ohiolink.edu/

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Feldges, Robert. "Mathematical Model of the Combined Effect of IL-6, TGF-beta and TNF-alpha on Pancreatic Stellate Cell Activation." Electronic Thesis or Dissertation. Ohio State University, 2015. OhioLINK Electronic Theses and Dissertations Center. 25 Sep 2017.

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Feldges, Robert "Mathematical Model of the Combined Effect of IL-6, TGF-beta and TNF-alpha on Pancreatic Stellate Cell Activation." Electronic Thesis or Dissertation. Ohio State University, 2015. https://etd.ohiolink.edu/

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