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Reproductive Benefits Conferred by Genetically Foreign Cells that Persist in Mothers and Offspring
Kinder, Jeremy M.

2016, PhD, University of Cincinnati, Medicine: Immunology.
Our genetic makeup is equally inherited from our mother and father through classical Mendelian genetics. However, each individual is constitutively chimeric, containing genetically foreign cells vertically transferred from their mothers during in utero development. These rare maternal microchimeric maternal cells have been identified to persist many years after birth and across a wide range of tissues demonstrating remarkable immune tolerance to our mothers persists in us long after we are born. Reciprocally during pregnancy, mothers also receive a transfer of fetal cells that persist after parturition. We have shown that transfer of these genetically foreign cells during gestation is not accidental, but instead these cells are intentionally retained to promote reproductive fitness in subsequent pregnancies. Herein, we will explore the teleological and immunological implications of the long-term retention these genetically foreign cells.
Sing Sing Way, Ph.D. (Committee Chair)
David Hildeman, Ph.D. (Committee Member)
Jonathan Katz, Ph.D. (Committee Member)
Aimen Shaaban, M.D. (Committee Member)
Harinder Singh (Committee Member)
227 p.

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Kinder, J. (2016). Reproductive Benefits Conferred by Genetically Foreign Cells that Persist in Mothers and Offspring. (Electronic Thesis or Dissertation). Retrieved from https://etd.ohiolink.edu/

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Kinder, Jeremy. "Reproductive Benefits Conferred by Genetically Foreign Cells that Persist in Mothers and Offspring." Electronic Thesis or Dissertation. University of Cincinnati, 2016. OhioLINK Electronic Theses and Dissertations Center. 22 Sep 2018.

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Kinder, Jeremy "Reproductive Benefits Conferred by Genetically Foreign Cells that Persist in Mothers and Offspring." Electronic Thesis or Dissertation. University of Cincinnati, 2016. https://etd.ohiolink.edu/

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Full text release has been delayed at the author's request until December 05, 2018