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A Two-Component Model For Bacterial Chemotaxis
Durney, Clinton H

2013, Master of Science, Ohio State University, Mathematics.
Chemotaxis is the directed cell movement in response to chemical signals. It is
crucial in many multicellular processes, such as wound healing, cancer metastasis,
embryonic development and bioremediation. Quantitative descriptions of chemotaxis
will lead to a better understanding of the mechanisms of chemotaxis and is essential
in understanding the aforementioned processes.

In this thesis, we study chemotaxis of the run-and-tumble bacteria E. coli. We
develop a mathematical model of E. coli chemotaxis at the single cell level. The model
consists of two modules: The fi rst describes how the cell transduces the external signal
into an internal signal (i.e. the change of the concentration of the intracellular protein
CheYP ). Our description is based on an existing "trimers of dimers" model and we
improve the parameter estimation in this work. The second module is the change of
cell movement in response to the internal CheYP change. We propose a new method
to interpret existing data on flagellar rotation. Finally we couple these two modules
and use the full model to simulate a population of cells.

Chuan Xue, Dr. (Advisor)
Ching-Shan Chou, Dr. (Committee Member)
Daniel Wozniak, Dr. (Committee Member)
51 p.

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Durney, C. (2013). A Two-Component Model For Bacterial Chemotaxis. (Electronic Thesis or Dissertation). Retrieved from https://etd.ohiolink.edu/

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Durney, Clinton. "A Two-Component Model For Bacterial Chemotaxis." Electronic Thesis or Dissertation. Ohio State University, 2013. OhioLINK Electronic Theses and Dissertations Center. 25 Sep 2017.

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Durney, Clinton "A Two-Component Model For Bacterial Chemotaxis." Electronic Thesis or Dissertation. Ohio State University, 2013. https://etd.ohiolink.edu/

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