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MICRO-GAS EXCHANGER FOR OXYGEN TENSION CONTROL IN BIOLOGICAL MICROFLUIDIC SYSTEMS
Kim, Myeongseop

2016, Master of Sciences, Case Western Reserve University, EMC - Mechanical Engineering.
Oxygen tension is a crucial element in physiologically relevant in vitro systems as cellular functions and behaviors are affected by oxygen tension. Often, hypoxic chambers and workstations, which are inconvenient for the user, have been used to control oxygen tension. The advancement of microfluidics has facilitated development of innovative devices to mimic physiological conditions such as oxygen tension. Soft-lithography-based microfluidic platforms have been widely utilized for their rapid prototyping capabilities and low-cost material requirements. However, these platforms pose critical shortcomings including labor-intensive fabrication processes. To overcome these challenges, a high-throughput, low-cost, single-use, clinically applicable, and easily implementable micro-gas exchanger integrated with a microfluidic chip is developed. With this system, a heterogeneity in individual sickle cell disease (SCD) patients’ response to hypoxia is observed in terms of increase in the number of adhered RBCs compared to normoxia. Furthermore, significant associations between SCD patients’ response to hypoxia and clinical phenotypes are found.
Umut Gurkan (Advisor)
Jane Little (Committee Member)
Ozan Akkus (Committee Member)
83 p.

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Kim, M. (2016). MICRO-GAS EXCHANGER FOR OXYGEN TENSION CONTROL IN BIOLOGICAL MICROFLUIDIC SYSTEMS. (Electronic Thesis or Dissertation). Retrieved from https://etd.ohiolink.edu/

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Kim, Myeongseop. "MICRO-GAS EXCHANGER FOR OXYGEN TENSION CONTROL IN BIOLOGICAL MICROFLUIDIC SYSTEMS." Electronic Thesis or Dissertation. Case Western Reserve University, 2016. OhioLINK Electronic Theses and Dissertations Center. 17 Oct 2017.

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Kim, Myeongseop "MICRO-GAS EXCHANGER FOR OXYGEN TENSION CONTROL IN BIOLOGICAL MICROFLUIDIC SYSTEMS." Electronic Thesis or Dissertation. Case Western Reserve University, 2016. https://etd.ohiolink.edu/

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Full text release has been delayed at the author's request until May 15, 2018