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The Design, Fabrication, and Testing of a Point of Care Device for Diagnosing Sickle Cell Disease and Other Hemoglobin Disorders
Ung, Ryan

2016, Master of Sciences (Engineering), Case Western Reserve University, Biomedical Engineering.
Every day, more than 1,000 children are born with sickle cell disease (SCD) in Sub-Saharan Africa. About 50-80% of these children die before the age of five due to lack of diagnosis. Current laboratory methods are too costly and resource-intensive for widespread diagnosis of SCD. The World Health Organization (WHO) has recognized the unmet need for early screening and diagnosis of SCD in newborns, and estimates that 70% of SCD related deaths are preventable with simple, cost-efficient interventions. To address this need, the HemeChip was developed as a point-of-care device for diagnosing SCD. With a finger-prick volume of blood, HemeChip identifies and quantifies hemoglobin types on a strip of cellulose acetate paper that is housed in a micro-engineered chip with a controlled environment and electrical field. The HemeChip results were validated and benchmarked against standard clinical hemoglobin screening methods, such as bench-top electrophoresis and high performance liquid chromatography.
Umut Gurkan, PhD (Advisor)
Kenneth Gustafson, PhD (Committee Chair)
Jane Little, MD (Committee Member)
61 p.

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Ung, R. (2016). The Design, Fabrication, and Testing of a Point of Care Device for Diagnosing Sickle Cell Disease and Other Hemoglobin Disorders. (Electronic Thesis or Dissertation). Retrieved from https://etd.ohiolink.edu/

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Ung, Ryan. "The Design, Fabrication, and Testing of a Point of Care Device for Diagnosing Sickle Cell Disease and Other Hemoglobin Disorders." Electronic Thesis or Dissertation. Case Western Reserve University, 2016. OhioLINK Electronic Theses and Dissertations Center. 17 Oct 2017.

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Ung, Ryan "The Design, Fabrication, and Testing of a Point of Care Device for Diagnosing Sickle Cell Disease and Other Hemoglobin Disorders." Electronic Thesis or Dissertation. Case Western Reserve University, 2016. https://etd.ohiolink.edu/

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Full text release has been delayed at the author's request until May 15, 2018