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THE MECHANISMS BY WHICH REPEATED STRESS EXPOSURE ALTERS BRAIN CYTOKINES: IMPLICATIONS FOR DEPRESSIVE-LIKE BEHAVIOR
Gabella, Kristin

2013, BS, Kent State University, College of Arts and Sciences / Department of Biological Sciences.
Major depression is a mental illness that can be debilitating to sufferers. Furthermore, it is relatively common and reoccurring. Recently, the macrophage hypothesis has been proposed and explains stimulation of the immune system to cause depression. Depressive-like behavior, in both humans and animal models, has been shown to be induced by Interleukin-1 (IL-1), a proinflammatory cytokine, which is secreted by the stimulation of the immune system. Studies have shown norepinephrine to be released and act on beta-adrenergic receptors, leading to IL-1 induction. While the link between the immune system and depression is being investigated, the effect of stress is now questioned. The aim of the current studies is to examine the link between chronic stress, the immune system, and depression. Fischer 344 rats were exposed to four days of chronic mild stress and beta-adrenergic receptor-mediated induction of IL-1 was observed in the prefrontal cortex, hypothalamus, hippocampus, amygdala, and brain stem. Chronically stressed animals demonstrated, regionally, that IL-1 induction is dependent on beta-adrenergic receptor stimulation. Our data also suggest regional priming of IL-1 levels is observed in chronically stressed animals, implying a possible mechanism of depression. While the data provides further information on the link between chronic stress, the immune system, and depression; the mechanism appears to be highly complex.
John Johnson (Advisor)

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Gabella, K. (2013). THE MECHANISMS BY WHICH REPEATED STRESS EXPOSURE ALTERS BRAIN CYTOKINES: IMPLICATIONS FOR DEPRESSIVE-LIKE BEHAVIOR. (Electronic Thesis or Dissertation). Retrieved from https://etd.ohiolink.edu/

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Gabella, Kristin. "THE MECHANISMS BY WHICH REPEATED STRESS EXPOSURE ALTERS BRAIN CYTOKINES: IMPLICATIONS FOR DEPRESSIVE-LIKE BEHAVIOR." Electronic Thesis or Dissertation. Kent State University, 2013. OhioLINK Electronic Theses and Dissertations Center. 02 Jul 2015.

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Gabella, Kristin "THE MECHANISMS BY WHICH REPEATED STRESS EXPOSURE ALTERS BRAIN CYTOKINES: IMPLICATIONS FOR DEPRESSIVE-LIKE BEHAVIOR." Electronic Thesis or Dissertation. Kent State University, 2013. https://etd.ohiolink.edu/

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