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THE INFLUENCE OF MODIFICATION OF BMAL1 EXPRESSION IN SKELETAL MUSCLE ON WHOLE-BODY METABOLISM AND FUNCTION
Mesfin, Fikir

2012, BS, Kent State University, College of Arts and Sciences / Department of Chemistry.
Circadian rhythm is one of the most fundamental regulators of physiology and behavior. The transcription-translation feed-back loop of clock genes control metabolic activity by regulating the transcription of key proteins and enzymes. The transcription proteins BMAL1 and CLOCK are two of the proteins that are involved in translation-transcription feed-back loop. They dimerize and bind to promoter regions and positively regulate the expression of other clock genes. The expressed clock proteins in turn can negatively regulate the action of CLOCK and BMAL1 and/or regulate the expression of other metabolic proteins. Because BMAL1 is an integral part of the circadian rhythm and its roles in whole-body metabolism, the modification of its expression can disrupt muscle metabolism. The overexpression of BMAL1 in skeletal muscles may have a broader impact on whole-body metabolic regulation.
Colleen Novak, PhD (Advisor)
Paul Sampson, PhD (Committee Member)
Eric Mintz, PhD (Committee Member)
Roger Gregory, PhD (Committee Member)
64 p.

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Mesfin, F. (2012). THE INFLUENCE OF MODIFICATION OF BMAL1 EXPRESSION IN SKELETAL MUSCLE ON WHOLE-BODY METABOLISM AND FUNCTION. (Electronic Thesis or Dissertation). Retrieved from https://etd.ohiolink.edu/

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Mesfin, Fikir. "THE INFLUENCE OF MODIFICATION OF BMAL1 EXPRESSION IN SKELETAL MUSCLE ON WHOLE-BODY METABOLISM AND FUNCTION." Electronic Thesis or Dissertation. Kent State University, 2012. OhioLINK Electronic Theses and Dissertations Center. 26 May 2015.

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Mesfin, Fikir "THE INFLUENCE OF MODIFICATION OF BMAL1 EXPRESSION IN SKELETAL MUSCLE ON WHOLE-BODY METABOLISM AND FUNCTION." Electronic Thesis or Dissertation. Kent State University, 2012. https://etd.ohiolink.edu/

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