Search ETDs:
Mechanistic Studies on the Reaction of Cob(I)alamin and Nitrite
Plymale, Noah T.

2011, BS, Kent State University, College of Arts and Sciences / Department of Chemistry.

Reactive oxygen species (ROS) and reactive nitrogen species (RNS), such as nitrite (NO2-) are small reactive molecules present naturally in biological systems. Elevated levels of ROS and RNS (oxidative / nitrosative stress) are associated with inflammatory diseases and cancer. Vitamin B12, known as cobalamin (Cbl), participates in two B12-dependent enzyme reactions in mammals that are inactivated during oxidative / nitrosative stress. Cob(I)alamin (Cbl(I)), an intermediate in the B12-dependent methionine synthase reaction and a biosynthetic precursor of the B12 coenzymes, is readily oxidized to cob(II)alamin (Cbl(II)).The kinetics of the reaction between Cbl(I) and NO2- have been investigated and a reaction mechanism proposed.

Nicola Brasch, PhD (Advisor)
Edwin Gould, PhD (Committee Member)
Brett Ellman, PhD (Committee Member)
Douglas Kline, PhD (Committee Member)
51 p.

Recommended Citations

Hide/Show APA Citation

Plymale, N. (2011). Mechanistic Studies on the Reaction of Cob(I)alamin and Nitrite. (Electronic Thesis or Dissertation). Retrieved from https://etd.ohiolink.edu/

Hide/Show MLA Citation

Plymale, Noah. "Mechanistic Studies on the Reaction of Cob(I)alamin and Nitrite." Electronic Thesis or Dissertation. Kent State University, 2011. OhioLINK Electronic Theses and Dissertations Center. 28 Aug 2015.

Hide/Show Chicago Citation

Plymale, Noah "Mechanistic Studies on the Reaction of Cob(I)alamin and Nitrite." Electronic Thesis or Dissertation. Kent State University, 2011. https://etd.ohiolink.edu/

Files

Full text release has been delayed at the author's request until December 31, 2016