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Prepulse Inhibition of the Startle Reflex in Forebrain Oxytocin Receptor Knockout Mice
Swonger, Jessica M.

2011, BS, Kent State University, College of Arts and Sciences / Department of Biological Sciences.
Oxytocin (Oxt) is a nine amino acid neuropeptide that has been studied for its role in social cognition and social behavior across species. To date, a single subtype of Oxt receptor, the Oxtr, has been identified. Oxt has also been implicated in several neuropsychiatric disorders including schizophrenia. One characteristic of schizophrenia is impaired sensorimotor gating, which is the ability to properly filter or “gate” sensory information. Across species, deficits in sensorimotor gating are measured using prepulse inhibition (PPI) of the startle reflex. PPI is the reduction in startle magnitude when a startling pulse is preceded by a smaller prepulse. In the current study we used conditional Oxtr knockout mice, where the disruption was specific to forebrain Oxtr (Oxtr FB/FB). Based on previous work in Oxt knockout mice, which have increased phencyclidine (PCP)-disrupted PPI, we hypothesized that treatment with psychotomimetics would result in greater PPI disruption in Oxtr FB/FB mice compared to wildtype (Oxtr +/+) controls. We used male and female Oxtr +/+ and Oxtr FB/FB mice and tested their PPI following treatment with the psychotomimetics: amphetamine (Amp), apomorphine (Apo), and PCP. We found that Oxtr FB/FB mice did not have significant differences in the disruption of PPI compared to Oxtr +/+ mice. This lack of effect cannot be attributed to an overall genotypic difference in PPI, as baseline testing found no differences in PPI between Oxtr +/+ and Oxtr FB/FB mice. In conclusion, our data suggest that Oxt signaling in the forebrain does not interact with PPI circuitry.
Heather Caldwell, PhD (Advisor)
Eric Mintz, PhD (Committee Member)
Manfred van Dulmen, PhD (Committee Member)
Chi-Hua Chiu, PhD (Committee Member)
55 p.

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Swonger, J. (2011). Prepulse Inhibition of the Startle Reflex in Forebrain Oxytocin Receptor Knockout Mice. (Electronic Thesis or Dissertation). Retrieved from https://etd.ohiolink.edu/

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Swonger, Jessica. "Prepulse Inhibition of the Startle Reflex in Forebrain Oxytocin Receptor Knockout Mice." Electronic Thesis or Dissertation. Kent State University, 2011. OhioLINK Electronic Theses and Dissertations Center. 26 Apr 2015.

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Swonger, Jessica "Prepulse Inhibition of the Startle Reflex in Forebrain Oxytocin Receptor Knockout Mice." Electronic Thesis or Dissertation. Kent State University, 2011. https://etd.ohiolink.edu/

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