Master of Science, The Ohio State University, 2024, Health and Rehabilitation Sciences
Background: Individuals with Huntington's disease (HD) with balance and gait impairments experience falls, which often leads to injuries and reduced quality of life. Therefore, clinicians need to identify individuals who are at risk of falling to prescribe appropriate fall prevention strategies.
Objectives: This study investigated the ability of a variety of clinical balance and gait assessments to differentiate between fallers and non-fallers and the accuracy of each assessment to determine fall risk.
Methods: Thirty-three individuals with diagnosed HD were recruited for the study (18 retrospectively identified fallers and 15 non-fallers). Each participant was evaluated with three categories of scales: HD-specific scales (Unified Huntington Disease Rating Scale total motor score [UHDRS-TMS] and UHDRS-TMS balance and gait subitems (i.e., gait, tandem walk, and retropulsion pull test), balance specific scales (Mini Balance Evaluation System Test [Mini-BESTest] and the Activities-Specific Balance Confidence Scale [ABC Scale]), and functional gait scales (Community Balance and Mobility Scale [CBM] and Functional Gait Assessment [FGA]).
Results: The discriminant function analysis determined that the best discriminators of faller or non-faller group memberships were the Mini-BESTest, CBM and the UHDRS-TMS balance and gait subitems. Receiver operating characteristic (ROC) curve was used to determine the best fall risk cutoff score. The highest three clinical tests had an area under the curve and a corresponding cut off score as follows: Mini-BESTest (0.774, ≤19/28), CBM (0.761, ≤37/96), and the UHDRS-TMS balance and gait subitems (0.728, ≥4/12). The odds ratio for the Mini-BESTest, CBM, and UHDRS-TMS balance and gait subitems were 7, 10.21, and 11.2, respectively. Using a pretest probability of 54%, and a positive likelihood ratio, the posttest probability changes were Mini-BESTest (73.2%), CBM (84.3%), and the UHDRS-TMS balance and gait subitems (88.6%).
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Committee: Anne Kloos (Advisor)
Subjects: Health Sciences; Neurosciences; Physical Therapy