PhD, University of Cincinnati, 2005, Arts and Sciences : Psychology
Diminished test performance on standard olfactory tasks is known to be related to the level of cognitive impairment in individuals with diverse neurologic and psychiatric disorders. It is unclear, however, to what extent olfactory losses reflect sensory dysfunction in the early stages of olfactory processing, pathology related to higher-order processing of odors, non-olfactory cognitive deficits that emulate or exacerbate the appearance of olfactory losses, or some combination of all of these factors. A novel, valid and reliable approach to the evaluation of olfaction, the Sniff Magnitude Test (SMT), was recently developed and may minimize the influence of non-olfactory cognitive information processes in the evaluation of olfactory functioning. Recently, the SMT was found to be a valid indicator of olfactory ability in children and individuals with limited English-language abilities, which provided preliminary support for the claim that the test is only minimally influenced by variations in attentional and memory capacities, as well as language and odor familiarity. The present study used analysis of covariance structure procedures to determine the extent to which measures of retrieval of semantic and episodic verbal information, working memory, and cognitive processing speed relate to 3 measures of olfaction believed to have differing degrees of cognitive complexity. One hundred thirty-eight adults (ages 56-93 years) completed a battery of neuropsychological tests and the SMT, the phenyl ethyl alcohol threshold test (PEAT), and the University of Pennsylvania Smell Identification Test (UPSIT). Results indicated that the retrieval of verbal information significantly affects the UPSIT, working memory significantly affects the UPSIT and to a lesser extent the PEAT, and cognitive processing speed significantly affects the UPSIT and to a lesser extent the PEAT. As predicted, verbal retrieval, working memory and cognitive processing speed did not influence performance on (open full item for complete abstract)
Committee: Dr. Robert Frank (Advisor)
Subjects: Psychology, Cognitive