Doctor of Philosophy, The Ohio State University, 2009, Biomedical Engineering
Velocity measurement based on phase-contrast magnetic resonance imaging (PC-MRI) is firmly recognized as a valuable and accurate technique to assess hemodynamics in a variety of clinical applications. However, conventional PC-MRI requires the acquisition of two separate and complete k-space dataset with different flow sensitivities. Real-time MR velocity measurement experiences limited success due to the insufficient temporal sampling rate to depict hemodynamic prosperities within each cardiac cycle. Accelerated data acquisition strategies described by this dissertation were developed to reduce the reference data requirements. Time-efficient PC-MRI methods accelerate the acquisition of phase-reference data in the spatial and temporal domain with minimum loss of velocity accuracy. Root-Mean-Square error estimation demonstrates the accuracy of the proposed accelerated velocity measurement methods as compared to the conventional PC-MRI reconstruction.
As an alternative accelerated PC-MRI, shared velocity encoding (SVE) method was developed to achieve the same temporal sampling rate comparing to standard MR cine scans. In SVE method, phase-difference images from alternative polarity pairs (+ -), (- +), (+ -), etc. can be reconstructed and resulted in a factor of 2 increase in the effective temporal resolution. With the SVE method implementation, the local pulse wave velocity (PWV) measurement becomes practical and useful in the common carotid arteries in current clinical 1.5T MRI scanners.
Echo-planar imaging (EPI) is an ultra-high-speed MRI method that is capable of producing snap-shot MR images in the ranges of 10-100 msec. Recently, EPI sequence has been used in attempts to acquire real-time cardiac cine images in a standard MR scan. Consequently, we propose to utilize the advantage of high acquisition speed of EPI combining with PC-MRI to achieve real-time velocity measurement in the major vessels. However, chemical shift artifacts resulting from the off-resonanc (open full item for complete abstract)
Committee: Orlando Simonetti PhD (Committee Chair); Subha Raman MD (Committee Member); Petra Schmalbrock PhD (Committee Member); Yiucho Chung PhD (Committee Member)
Subjects: Biomedical Research