PhD, University of Cincinnati, 2017, Medicine: Neuroscience/Medical Science Scholars Interdisciplinary
Background – Radiation therapy (RT) is a very common treatment for pediatric brain tumors. Unfortunately, RT is associated with long-term cognitive impairments. White matter (WM) tracts, such as the corpus callosum (CC), mediate processing speed which , in turn, mediates overall cognitive ability. Pediatric RT patients experience WM deficits and long-term deficits in processing speed and intelligence quotient (IQ). However, long-term effects of RT on WM integrity in these patients are unknown. Patients who receive RT frequently undergo surgery, but it is unclear how surgery affects long-term WM integrity and cognitive ability. WM integrity, age, gender, highest parent education and occupation, and family income are affecters of intelligence, but their effects on cognitive ability in pediatric RT patients are unknown.
Objective - 1) to determine the long-term effects of RT on CC integrity as well as processing speed and IQ two years after treatment while controlling for surgery; 2) To determine the effects of non-treatment, intelligence-associated factors on post-treatment cognitive ability; 3) to quantity the relationship between radiation dose and WM integrity in pediatric brain tumor patients.
Methods –Diffusion tensor imaging (DTI) was used to quantify WM integrity of the genu (GCC), body (BCC), and splenium (SCC) of the CC. Preschool, child, and adult variants of the Wechsler intelligence assessments measured processing speed and IQ. Participants included pediatric brain tumor patients diagnosed between 3 and 16 years old. They underwent baseline evaluations 3 to 12 months after surgery, and approximately two years later. Participants treated with surgery and RT were matched to those who didn't receive RT. Baseline and two-year DTI, processing speed, and IQ data were compared between groups at each time point and to each other within each group. Along with RT status, factors including baseline BCC integrity, age, gender, highest parent education and occupa (open full item for complete abstract)
Committee: Kim Cecil Ph.D. (Committee Chair); Caleb Adler Ph.D. (Committee Member); Scott Holland Ph.D. (Committee Member); Trent Hummel M.D. (Committee Member); Michael Lamba Ph.D. (Committee Member)
Subjects: Neurology