PhD, University of Cincinnati, 2021, Allied Health Sciences: Communication Sciences and Disorders
In typical child and adult speakers, speech generation requires coordinated activation of a network of inferior frontal, temporal, and subcortical brain regions to carry out multiple linguistic and speech motor processes. However, a portion of children who exhibit speech sound errors in development persist in these errors beyond age 9, which can lead to broader, long-term consequences in scholastic achievement, literacy, and social-emotional well-being. The goal of this project was to investigate the neural underpinnings of residual speech sound disorder (RSSD) and its remediation through a speech therapy program.
In Study 1, I investigated the neural activity of children with RSSD in comparison to children with typically-developing speech (TD) at baseline (Time 1). I had anticipated to observe significant differences between RSSD and TD groups. However, in a whole-brain analysis (at p<0.05 and with Bonferroni corrections for multiple comparisons), I did not observe statistically significant differences in activation on either the SRT-Early Sounds or SRT-Late Sounds.
In Study 2, I followed up with a region-of-interest approach of activation at Time 1 and Time 2. I did not detect any significant differences across task, group, or time comparisons. While this finding was not expected, it implies that, when task performance is similar, children with RSSD do not show differences in neural activity from their typical peers. I also explored the relationship between change in activation and progress in therapy. I found that children with RSSD who made more progress in therapy tended to show a decrease in activation in the left visual association cortex on the SRT-Late Sounds (R2=0.78). The left visual association cortex is not a core component of the speech production network but may indicate differences in the children's reliance on sensorimotor integration or internal speech visualization processes.
Using a seed-to-voxel approach, I also explored function (open full item for complete abstract)
Committee: Suzanne Boyce Ph.D. (Committee Chair); Edwin Maas Ph.D. (Committee Member); Jonathan Preston Ph.D. (Committee Member); Erin Redle Ph.D. (Committee Member); Jennifer Vannest Ph.D. (Committee Member)
Subjects: Speech Therapy