PhD, University of Cincinnati, 2024, Engineering and Applied Science: Biomedical Engineering
This dissertation presents a multi-faceted investigation into the fluid-structure interactions (FSI), glottal flow dynamics, and acoustic outcomes across a variety of vocal fold models, including cadaveric human, excised canine, and synthetic vocal folds. By combining experimental methods such as planar particle image velocimetry (PIV), tomographic PIV (tomo-PIV), and computational simulations, this work aims to deepen our understanding of phonation mechanics, with implications for clinical voice research and synthetic model development. The first study explores subglottal stenosis and its significant impact on airway resistance, demonstrating through computational fluid dynamics (CFD) simulations that severe constriction leads to sharp increases in turbulent kinetic energy (TKE), supporting the use of virtual surgical planning to manage stenosis. The second study compares the aerodynamic and elastic properties of human, canine, and synthetic vocal folds, emphasizing the presence of vertical stiffness gradients (VSG) and flow separation vortices (FSV) in biological models. These findings underline the biomechanical complexity of tissue models and their implications for phonation, while identifying limitations in synthetic models, such as the absence of a VSG. The third study characterizes the VSG along the anterior-posterior axis in canine and human vocal folds, confirming the relevance of canine models in representing human tissue behaviors. The work enhances our knowledge of vocal fold elasticity, offering valuable data for both experimental and numerical models of phonation. The fourth study focuses on the FSI within the vocal folds, using ex-vivo canine larynges to capture intraglottal flow fields and characterize how VSG and glottal geometry influence phonatory efficiency and vortex formation. The results show that FSI is the primary factor for glottal flow skewing, advancing the understanding of three-dimensional (3D) flow dynamics during phonation. The fifth (open full item for complete abstract)
Committee: Liran Oren Ph.D. (Committee Chair); Charles Farbos de Luzan Ph.D. (Committee Member); T. Douglas Mast Ph.D. (Committee Member); Ephraim Gutmark Ph.D. (Committee Member)
Subjects: Biomedical Engineering