The present study investigated attitudes toward help-seeking and mental illness between adolescents residing in rural and urban areas in the Southeastern United States. On a single occasion, a total of 182 students from grades nine through twelve (89 students in rural sample, 93 students in urban sample) completed a series of questionnaires that assessed their attitudes toward mental illness and seeking help for psychological problems. To make the samples similar, this study controlled for an indicator of participants' socioeconomic status (SES). Results revealed that the rural adolescent sample endorsed significantly more negative attitudes toward seeking help for psychological problems compared to the urban adolescent sample. In contrast, results indicated no significant difference between rural and urban adolescents' attitudes toward mental illness. Both rural and urban adolescents, however, endorsed somewhat negative attitudes toward mental illness. Results of additional research questions provide information regarding what kinds of problems rural and urban adolescents might seek help for, whom rural and urban adolescents might seek help from, and what might prevent rural and urban adolescent from seeking help for a psychological problem. This study has implications for future mental health educational efforts and for addressing the unmet mental health needs of rural and urban youth.