Doctor of Philosophy, The Ohio State University, 2011, Human Ecology: Human Nutrition

Polyunsaturated fatty acids of the omega-3 (n-3) and omega-6 (n-6) families may differentially modulate osteoporotic fracture risk. This research uses the Women's Health Initiative (WHI) cohort to examine dietary intake, as well as red blood cell (RBC) FAs, in relation to bone mineral density (BMD) and fracture risk. The objective of the first research project was to examine FA intake, specifically n-3 and n-6 FAs, as well as the type of n-3 FA (marine versus non-marine sources) relative to osteoporotic fractures. Participants were 137,486 postmenopausal women enrolled in the WHI Clinical Trials and Observational Study. Total fractures were identified by self-report; hip fractures were confirmed by medical record review. FA intake was estimated from baseline food frequency questionnaires and standardized to total caloric intake. No data on n-3 FA supplementation was available. Cox proportional hazard models were constructed to estimate risk of fracture. Women in the highest quartile of saturated FA (SFA) intake had a 31% increase in relative risk for hip fracture. Both higher monounsaturated FA (MUFA) and polyunsaturated FA (PUFA) were associated with a small decrease (5-6%) in total fracture risk. Unexpectedly, higher consumption of marine n-3 FAs was associated with a 7% increase in total fracture risk whereas higher n-6 FA intake was associated with 6% lower total fracture risk. These results suggest SFA intake may increase hip fracture risk, while MUFA and PUFA may decrease total fracture risk. In postmenopausal women with low intake of marine n-3 FAs, higher intake of n-6 FAs may modestly decrease total fracture risk. To address limitations of this project such as inability to capture n-3 FA supplement use and error associated with self-reported intake, we examined RBC FAs in relation to hip fractures using a nested case/control design (n=400 pairs) within WHI. Frozen RBCs collected at baseline were analyzed for FA content using gas chromatography. Hip fract (open full item for complete abstract)

Committee: Rebecca Jackson (Advisor); Martha Belury (Committee Member); Steven Clinton (Committee Member); Diane Habash (Committee Member) Subjects: Epidemiology; Health; Nutrition; Public Health

Doctor of Philosophy, The Ohio State University, 2022, Nutrition Program, The Ohio State University

Branched-chain amino acids (BCAA; valine, isoleucine, and leucine) can be deaminated by many amylolytic bacteria to branched-chain volatile fatty acids (BCVFA, isobutyrate, 2-methylbutyrate, and isovalerate), which are growth factors for some cellulolytic bacteria. Many cellulolytic bacteria cannot uptake BCAA or decarboxylate them, thus depending on cross feeding for BCVFA precursors for carboxylation to BCAA or synthesis of branched-chain fatty acids (BCFA; iso even-chain, iso odd-chain, and anteiso odd-chain) and branched-chain aldehydes (BCALD) found in bacterial phospholipid and plasmalogens, respectively. Supplemental BCVFA and valerate, a straight-chain volatile fatty acid (VFA) that is also a growth factor for some rumen bacteria, have been previously supplemented together in a combination commonly referred to as ‘isoacids'. However, prior in vivo studies have either provided only one BCVFA individually or all BCVFA and valerate but not different combinations of isoacids. Our objective in the first study was to determine an optimal combination of isoacids. Sixty (28 primiparous and 32 multiparous) lactating Jersey cows (106 ± 54 days in milk) were blocked and randomly assigned to either a control (CON) treatment without any isoacids, 2-methylburtyate (MB, 12.3 mmol/kg DM), 2-methylbutyrate and isobutyrate (MB + IB, 7.7 and 12.6 mmol/kg DM of MB and IB), or all 4 isoacids (ISO, 6.2, 7.3, 4.2, and 5.1 mmol/kg DM of MB, IB, isovalerate, and valerate, respectively). The CON diet was fed for 2-wk covariate period, then cattle were fed their assigned treatment for the 8-wk sampling period (n=15). Daily intake and milk yield were recorded and samples from 4 consecutive milkings a week were analyzed for milk components. The milk fatty acid profile was analyzed on wk 5 and wk 9. Treatment tended to interact with parity for both fat and protein concentrations. Primiparous cows did not differ by treatment, whereas multiparous cows supplemented with MB + IB tended to h (open full item for complete abstract)

Committee: Jeffrey Firkins (Advisor); Zhongtang Yu (Committee Member); Robin White (Committee Member); Chanhee Lee (Committee Member) Subjects: Animal Sciences; Microbiology; Nutrition

Master of Science, The Ohio State University, 2007, Graduate School

Committee: Not Provided (Other) Subjects:

Master of Science (MS), Bowling Green State University, 2020, Biological Sciences

Industrial processing of soybeans to produce soy oil and soy meal results in soybean seed coats as a low value waste product that is underutilized. Pythium are rapidly growing plant pathogens that secrete a large number of carbohydrate-digesting enzymes that possess the ability to breakdown the fibrous carbohydrates present in soybean seed coats to release the required carbon for their growth. We tap into this potential of oomycetes and utilize soybean seed coats as a source of carbon for the growth of Pythium under microaerobic, aerobic conditions and 4% sucrose supplementation to produce proteins and the important omega three and omega six fatty acids that can be included in fish feed as an alternative source of fish oil and proteins. Biomass produced by growing cultures on this carbohydrate source and inorganic N has a protein content exceeding 20% with a very favorable amino acid profile. Microaerobic culture conditions produce an unsaturated and saturated fatty acid mixture that mimics that of salmon and sardine oil. Aeration of samples and supplementation with 4% sucrose during the growth process significantly increases the amounts and variety of omega fatty acids produced. The results of this study suggest that soybean seed coats are a viable source of carbon for Pythium in the production of omega three and omega six fatty acids and proteins for aquaculture.

Committee: Paul Morris PhD (Advisor); Kevin Neves PhD (Committee Member); Vipaporn Phuntumart PhD (Committee Member); Travis Worst PhD (Committee Member) Subjects: Biochemistry; Biology; Fish Production; Food Science; Microbiology; Molecular Biology; Nutrition

Master of Science (M.S.), University of Dayton, 2013, Chemical Engineering

Biological oils are potential sources of liquid transportation fuels. In the presence of a precious metal catalyst under reducing conditions, the transformation of biological oils to liquid fuels proceeds sequentially. First, any double bond is quickly saturated. The double bond saturation is followed by the hydrogenolysis of the ester linkages which releases the saturated fatty acids from the propane backbone. The fatty acids are then deoxygenated producing n-alkanes. Typically, the n-alkanes are further treated to meet the required physical properties of a particular fuel fraction. Although important, the deoxygenation of the fatty acid had not yet been studied in production-like conditions. For this reason, in this study, a comprehensive investigation of the deoxygenation of a representative fatty acid was carried out by studying stearic acid (S.A.) diluted in a highly isomerized C24 solvent. The deoxygenation of stearic acid was studied in the presence of hydrogen, in a trickle-bed reactor by using a 3 wt % carbon-supported palladium catalyst. In order to simplify the study of the kinetics of the S.A. deoxygenation, a uniform S.A. concentration across the catalyst bed was desired. For this reason, the entire study was conducted under differential conditions, by limiting the S.A. conversion to 10 percent. The limited conversion allowed me to assume uniform S.A. concentration across the catalyst bed. The liquid products were identified early on as n-heptadecane, n-octadecane, and stearyl stearate. The rate of formation for each liquid product was examined over wide-ranging sets of temperature, initial S.A. concentration and hydrogen pressure. Kinetic data for the different products were graphically derived and rate expressions were developed and presented. The S.A. deoxygenation reaction network in the presence of hydrogen was found to be rather complex. The observed rate of n-heptadecane production was a combined rate of two reactions, the steari (open full item for complete abstract)

Committee: Heinz Robota J. (Advisor); Kevin Myers J. (Committee Chair); Amy Ciric R. (Committee Member) Subjects: Alternative Energy; Chemical Engineering; Chemistry; Energy; Materials Science; Organic Chemistry; Physical Chemistry

Doctor of Philosophy, The Ohio State University, 2012, Psychology

Background: Depressive symptomatology has been associated with polyunsaturated fatty acid (PUFA) levels in diet and tissue. However, results have been mixed, and studies have failed to account for genetic factors that may influence such associations. Tissue PUFA levels are strongly influenced by elongase and desaturase activity, which are governed by the fatty acid desaturase (FADS) genes. Inefficient desaturase activity has been associated with depression. Further, FADS genotypes have been associated with neuropsychological phenotypes such as postpartum depression. Given these associations, the study of relationships among dietary PUFA intake, FADS genotype, and mood symptoms is warranted. Aims: The present study investigated associations among dietary intake of PUFAs, the rs174575 polymorphism of the fatty acid desaturase (FADS2) gene, and psychological outcomes. The primary aim was to determine if FADS2 genotype interacts with omega-3 (n-3) and omega-6 (n-6) PUFA dietary intake to influence associations with depressive symptoms, anxiety symptoms, anger, hostility, neuroticism, or optimism. Methods: A sample of 172 female undergraduate students provided genetic material from buccal cells, and completed a food frequency questionnaire and self-report measures including the Center for Epidemiological Studies Depression Scale, PROMIS Anxiety and Anger Scales, Cook Medley Hostility Scale, NEO Neuroticism Scale, and LOT-R Optimism Scale. Results: The main finding was that higher n-3 intake was associated with greater hostility. However, n-3 intake was not related to depressive symptoms, anxiety, anger, neuroticism, or optimism, nor was n-6 intake. Further, genotype did not interact with PUFA intake for any psychological outcomes. Conclusion: This study provided no evidence that the rs174575 fatty acid desaturase polymorphism influences associations between PUFA intake and mood.

Committee: Janice Kiecolt-Glaser PhD (Advisor); Charles Emery PhD (Committee Member); Ruchika Prakash PhD (Committee Member) Subjects: Psychology

Doctor of Philosophy, The Ohio State University, 2010, Nutrition Program, The Ohio State University

Epidemiological evidence suggests that prostate cancer, the most commonly diagnosed cancer in males, can be modulated by diet. Data exists that implicate both bioactive lipids and the vitamin D/ calcium axis in prostate cancer pathogenesis. These data suggest that bioactive lipids such as omega-3 fatty acids protect against prostate cancer, whereas omega-6 fatty acids promote prostate cancer. Population studies also indicate that a diet high in vitamin D decreases prostate cancer risk while calcium increases risk for prostate cancer, possibly by lowering circulating levels of protective vitamin D. However, critical experiments have not been performed in well characterized animal models. We therefore evaluated prostate carcinogenesis in murine models that utilize the SV40 Tag transformation system- TRAMP and Apt121/Rbf. We characterized these models with respect to time to tumor development, tumor size and metastasis. We evaluated prostate lesions using established histopathological criteria and assessed the expression of biomarkers that are related to the hallmarks of cancer. From these studies we can conclude that the TRAMP model is very aggressive and that the entire carcinogenic cascade is not represented, making dietary prevention interventions difficult. However, the Apt121/Rbf is a model of early prostate carcinogenesis and more appropriate for nutritional studies. We next investigated the effects of dietary bioactive lipids in the TRAMP murine model of prostate cancer. Male TRAMP mice were fed high fat diets that utilized fish oil or corn oil as the primary lipid source. The effects of bioactive lipids on TRAMP carcinogenesis were assessed using parameters related to prostate carcinogenesis. These included time to tumor development, tumor size and histopathologic grade/classification and presence of metastasis. Markers of lipid metabolism, including tissue prostaglandin and fatty acid profiles, were utilized to ensure bioavailability to the prostate. We foun (open full item for complete abstract)

Committee: Steven Clinton MD, PhD (Advisor); Charles Brooks PhD (Committee Member); Mark Failla PhD (Committee Member); Kichoon Lee PhD (Other) Subjects: Molecular Biology; Nutrition

Master of Science, The Ohio State University, 2009, Human Nutrition and Food Management

The Women's Diabetes Study was a clinical research study designed to evaluate the efficacy of fatty acid supplementation to the diet of post-menopausal women with diabetes. Conjugated linoleic acid and safflower oil were the treatment oils administered in this randomized, crossover design study. The purpose of this thesis research is to examine the baseline data taken from week 0 of the Women's Diabetes Study in order to assess the relationships between dietary fatty acid consumption, plasma fatty acids, and markers of health. This is therefore, an observational study, a secondary analysis of the Women's Diabetes Study.The first hypothesis states that dietary fatty acid consumption would predict for plasma fatty acid composition. The second hypothesis states that plasma fatty acids would predict for health markers including fasting glucose, HbA1c, insulin, QUICKI, HOMA IR, total, LDL, and HDL cholesterol, CRP and IL6, two markers of inflammation, waist circumference, total body and trunk fat as measured by DEXA, adiponectin, and leptin. Two resulting aims from these hypotheses were to determine if underreporting of energy consumption could have confounded the dietary results and whether the use of oral hypoglycemic and statin medications could impact the markers of health. We had anticipated correlations for linoleic acid, C18:2n6, an essential fatty acid, and for elaidic acid, C18:1n9, the most common industrially produced trans fat in the diet since neither are synthesized in the body; however, dietary and plasma levels of linoleic acid and elaidic acid were not correlated. Instead, dietary myristic acid, C14:0, was positively correlated with its plasma fatty acid. These data were unable to show a consistent relationship between diet and plasma fatty acid composition. Upon examining the resting metabolic rate (RMR) as computed from the Mifflin St. Jeor equation, 32% of the subjects had less energy intake than their RMR. This suggests that energy intake was underr (open full item for complete abstract)

Committee: Martha Belury PhD (Advisor); Jackie Buell PhD (Committee Member); Ziouzenkova Ouliana PhD (Committee Member) Subjects: Nutrition

Master of Science, The Ohio State University, 1967, Graduate School

Committee: Not Provided (Other) Subjects:

Master of Science, The Ohio State University, 1921, Graduate School

Committee: Not Provided (Other) Subjects:

Master of Science, The Ohio State University, 1921, Graduate School

Committee: Not Provided (Other) Subjects:

Master of Science, The Ohio State University, 2007, Graduate School

Committee: Not Provided (Other) Subjects:

Master of Science, The Ohio State University, 2007, Graduate School

Committee: Not Provided (Other) Subjects:

Doctor of Philosophy, The Ohio State University, 2024, Human Ecology: Human Nutrition

Chemotherapy is a common cancer treatment that induces neuroinflammation and may contribute to cancer-related cognitive impairment (CRCI). A higher intake of Omega-3 polyunsaturated unsaturated fatty acids (PUFAs) may reduce inflammation. In our previous mouse model of chemotherapy, Eicosapentaenoic acid (EPA) and Docosahexaenoic Acid (DHA)-enriched diets were shown to reduce pro-inflammatory biomarkers in the cortex, including Interleukin-6 (IL-6) and Keratinocyte chemoattractant / growth-regulated oncogene (KC/GRO) in the context of a background diet low in fat (19% of kilocalories). Considering that the majority of breast cancer survivors are overweight or obese at the time of diagnosis and high-fat diets can promote the develoment of obesity, EPA and DHA in diets with different fat contents should be evaluated to determine effects on neuroinflammation and neurodegeneration. In addition, the association of blood levels of fatty acids with cognitive function and the underlying mechanisms of CRCI have not been well studied in breast cancer survivors. In addition to omega-3 PUFAs, omega-6 PUFAs are also important for inflammatory processes. Moreover, we have found omega-9 monounsaturated fatty acids (MUFAs) to rise in mice brain after chemotherapy treatment, potentially suggesting neurodegeneration. Therefore, this dissertation will focus on understanding the relationship of fatty acids in the diet and blood, including omega-3 and omega-6 PUFAs and omega-9 MUFAs, with neuroinflammation, neurodegeneration, and cognitive outcomes in a chemotherapy-treated mouse model and human breast cancer survivors. The first project of this dissertation evaluated whether a diet rich in long-chain omega-3 fatty acids, eicosapentaenoic acid, and docosahexaenoic acid (EPA and DHA) could reduce neuroinflammation and neurodegeneration in a mouse model of chemotherapy. In this study, female C57BL/6 mice were randomized to high fat, high fat omega-3, or low-fat diet groups for 8 week (open full item for complete abstract)

Committee: Tonya Orchard (Advisor); Martha Belury (Committee Member); Darrin Aase (Committee Member); Patrick Schnell (Committee Member); Ouliana Ziouzenkova (Committee Member) Subjects: Cognitive Psychology; Neurobiology; Nutrition; Oncology

Doctor of Philosophy, The Ohio State University, 2024, Chemistry

Ocean worlds are defined as bodies throughout the solar system that are known or theorized to contain a large amount of liquid water. Most notably, Earth is an ocean world. Additionally, there are many moons and exoplanets that are also considered to be ocean worlds including Enceladus, a moon of Saturn, among others. Understanding the complex chemical environment of these oceans is important to elucidating the potential chemical reactions occurring on these different interstellar bodies. This includes our ability to find life or lifelike processes on other planets and moons. Performing measurements during planetary missions is incredibly challenging and a great deal of work has been done to improve instrumentation and analysis to increase the impact of mission returned data. Implementing machine learning techniques to the planetary instrumentation data pipeline is another promising way to help further improve our understanding of these systems. In this dissertation machine learning algorithms are used in a variety of methods to answer both categorical and numerical questions to this end. Classification type machine learning questions have been used to classify the presence of functional groups in analyte molecules using only an electron ionization mass spectrum through logistic regression. Regression based machine learning has been used to develop methods for identifying concentrations of organic classes of compounds (saccharides, fatty acids, and amino acids) in marine samples. This has been accomplished both with a single analyte and with multiple analytes. Support vector regression proved to be the most effective and accurate at identifying the concentrations of these compounds in a complex chemical matrix. Beyond only training accurate models, this research also utilizes and develops methodology to further analyze the embedded reasoning behind the model's assignments. These methods included feature analysis, which involved evaluating the associated wei (open full item for complete abstract)

Committee: Heather Allen (Advisor); Abraham Badu-Tawiah (Committee Member); Zachary Schultz (Committee Member); Morgan Cable (Committee Member) Subjects: Analytical Chemistry

Doctor of Philosophy in Clinical-Bioanalytical Chemistry, Cleveland State University, 2023, College of Sciences and Health Professions

Short-chain fatty acids (SCFAs) are important metabolites produced by gut microbial fermentation of dietary fibers in the human colon. They play an essential role in maintaining gut health by regulating inflammation and providing energy to colonocytes. Alterations in SCFAs levels, arising from dysbiosis, have implications in various diseases, including inflammatory bowel disease (IBD), colorectal cancer, and obesity. Thus, analyzing SCFA levels in fecal samples can provide valuable insights into the gut microbial environment and its association with disease pathogenesis and progression, potentially serving as a diagnostic tool or therapeutic target for various gastrointestinal and metabolic disorders. This dissertation presents a robust and reliable method for quantifying SCFAs in human fecal samples using GC-MS. The study involved the optimization of sample preparation and chromatographic conditions to achieve accurate and reproducible quantification of SCFAs in fecal samples. This method was applied to quantify SCFAs in fecal samples from IBD patients.

Committee: Baochuan Guo (Advisor); Michael Kalafatis (Committee Member); David Anderson (Committee Member); Valentin Gogonea (Committee Member); Jan Claesen (Committee Member) Subjects: Analytical Chemistry; Biochemistry

Master of Science, University of Toledo, 2023, Chemical Engineering

Multilayer plastics (MLPs) have become one of the most common food packaging materials. By combining multiple polymer types with distinct advantageous properties (e.g., water, light, or oxygen barrier properties), they extend the product shelf life while using less material. Yet, MLPs are challenging to recycle because their layers are difficult to separate, and this difficulty now presents a formidable sustainability challenge. To this end, we have developed new tie-layer materials through the complex coacervation (i.e., self-assembly) between the cationic polyelectrolyte, polyallylamine (PAH) and unsaturated, anionic fatty acids (either oleic acid or linoleic acid). Akin to the liquifying effects of double bonds in cis-unsaturated fats, the double bonds in these fatty acid tails imparted the otherwise-flaky PAH/surfactant complex precipitates with either moldable semisolid or liquid (coacervate) properties. These coacervates were prepared in two different solvents (water and ethanol) and were capable of (1) adhering two dissimilar plastic layers, (2) dissociating during recycling, thus enabling facile separation of MLP layers for further processing, and (3) as a bonus, serving as oxygen scavengers. These complexes exhibited tunable rheological properties, which ranged from viscous liquids (when solvated in ethanol) to putty-like semisolids (when formed in water) and coincided with solvent-dependent changes in their microstructure, where replacing water with ethanol led to a disruption of their lamellar order. Moreover, when prepared as low-viscosity dispersions of submicron coacervate droplets suspended in ethanol, these coacervates could be easily spread onto plastic substrates and (on partial drying) formed adhesive films that could bond dissimilar plastic layers, such as polyethylene terephthalate (PET), low-density polyethylene (LDPE), and ethylene vinyl alcohol (EVOH), with fewer defects and higher adhesion strengths than those achieved by spreading macro (open full item for complete abstract)

Committee: Yakov Lapitsky (Committee Chair); Maria Coleman (Committee Member); Joseph Lawrence (Committee Co-Chair) Subjects: Chemical Engineering; Chemistry; Packaging

Master of Arts (MA), Bowling Green State University, 1966, Biological Sciences

Committee: Robert Hutchison (Advisor) Subjects: Biology

Doctor of Philosophy, Case Western Reserve University, 2022, Chemistry

The intracellular lipid binding protein (iLBP) known as Fatty Acid Binding Protein 5 (FABP5) has become an attractive target for therapies of metastatic cancers and diseases associated with cognitive dysfunction, i.e., Alzheimer's /Dementia, and. This small monomeric protein with its target nuclear receptor, PPARδ, when activated by atRA has demonstrated pro-oncogenic activity within various cancers. This suggests that a novel route of therapy would be to inhibit FABP5, and push atRA to the canonical CRABP2:RAR pathway resulting in cellular death. Yet the complete inactivation of FABP5 could be detrimental in biological settings that govern cognitive function. FABP5: PPARδ plays a pivotal role in neuronal development and maturation, leading to overall regulation of learning and memory. Therefore, modulation of FABP5 must strategically be done through the use of either small molecule inhibitors or with its natural ligands, long chain fatty acids. The modulation of FABP5 by either small molecules or fatty acids greatly relies on whether these ligands activate FABP5's unique nuclear localization sequence (NLS). Ligands must fit into the beta clam binding pocket in such a way that allows for proper formation of the NLS, thus initiating translocation. Once into the nucleus, FABP5 will deliver its ligand to PPARδ initiating gene expression associated proliferation, differentiation, growth and cognition. The central hypotheses of the research projects presented herein are twofold 1) Inhibition of FABP5 in retinoic acid resistant cancers shifts atRA signaling back to the canonical pathway of CRABP2/RAR leading to cellular apoptosis and reduction in tumor growth. 2) FABP5 can be modulated by dietary long chain fatty acids to impact cognitive function through regulation of PPARδ transcriptional activity. This pathway within neurons thus leads to the improvement or hinderance of learning as well as memory, dependent upon the fatty acid (open full item for complete abstract)

Committee: Liraz Levi (Advisor); Gregory Tochtrop (Advisor); Blanton Tolbert (Committee Member); Irene Lee (Committee Member); Robert Salomon (Committee Chair) Subjects: Chemistry; Molecular Biology; Neurobiology; Oncology

Master of Science, The Ohio State University, 2021, Human Ecology: Human Nutrition

Background: Chemotherapy induces an inflammatory state. Polyunsaturated fatty acids (PUFAs) are potent signaling molecules that can alter inflammation. Objective/Hypothesis: The objective of this research was to examine serum inflammatory markers and fatty acids, and associations of serum PUFAs with inflammatory markers, in postmenopausal breast cancer patients before, during, and after chemotherapy. Methods: Serum samples from women undergoing treatment for breast cancer were collected prior to chemotherapy (baseline; n=53), just after the fourth cycle of chemotherapy (C4D1; n=40), and 6 months after beginning chemotherapy (6M; n=34). Serum fatty acids were extracted, methylated, then analyzed using gas chromatography; inflammatory markers were analyzed using multiplex enzyme-linked immunoassay. Data were natural log-transformed when appropriate and analyzed by one-way analysis of variance (ANOVA) by timepoints, followed by post-hoc tests using Tukey's Honest Significant Difference. Pearson's correlations were calculated to assess associations between inflammatory markers and PUFAs. Multivariate regression models were constructed to further assess PUFA and inflammatory marker associations controlling for body mass index (BMI), intervention treatment group, and baseline cytokine levels. p<0.05 was considered statistically significant for all analyses. Results: Results of ANOVA demonstrated significant changes in Linoleic acid (LA), Docosapentaenoic Acid (DPA-n6), and Docosahexaenoic Acid (DHA) as chemotherapy progressed. Post-hoc tests revealed that DPA-n6 significantly increased from baseline to C4D1, while DHA significantly increased from C4D1 to 6M (p<0.05 for both), but post-hoc tests did not detect differences between timepoints in LA. No significant changes were found in inflammatory markers during chemotherapy. LA, total n-6 PUFAs, and total PUFAs were significantly inversely correlated with inflammatory markers at all three timepoints. Significan (open full item for complete abstract)

Committee: Tonya Orchard PhD (Advisor); Ouliana Ziouzenkova PhD (Committee Member); Irene Hastu PhD (Committee Member) Subjects: Nutrition