Doctor of Philosophy, The Ohio State University, 2005, Ohio State University Nutrition
Prostate cancer is a major cause of morbidity and mortality in the United States. Epidemiologic, in vitro, and animal studies support the hypothesis that dietary patterns and nutritional compounds can influence prostate carcinogenesis. Prostate cancer generally has a protracted time course, therefore, many opportunities exist for nutritional interventions to alter the course of disease. This thesis involves three studies that target men during: 1) primary prostate cancer prevention, 2) treatment for localized disease and 3) treatment for advanced disease. The first study quantifies the use of nutritional supplements in a subgroup of men participating in a large, nationwide chemoprevention trial. We found that a majority of men were consuming supplements which are hypothesized to influence prostate cancer risk and therefore, may impact the results of prevention studies. Our second study precisely defines nutritional supplement use among men undergoing radiation therapy for primary treatment of newly diagnosed, localized prostate cancer. There are very few reports describing supplement use among men actively undergoing treatment for prostate cancer, and how dietary supplements may influence radiation therapy is currently an area of controversy. We found a majority of men were consuming supplements, many of which have been hypothesized to influence the efficacy or toxicity of radiation therapy. Our third study is an intervention trial where we evaluated adherence, safety, and biological effects of a diet rich in tomatoes / tomato products and soy foods in men with advanced prostate cancer. A diet rich in tomatoes and soy foods was tolerable and did not result in significant toxicity. Additionally, we observed that a diet rich in tomatoes and soy protein reduced serum PSA in 30 to 40% of men and may prolong the interval before more aggressive cancer therapy is needed. These studies indicate that men at risk of prostate cancer or undergoing primary treatment consume supp (open full item for complete abstract)
Committee: Steven Clinton (Advisor)
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