Master of Science, The Ohio State University, 2020, Vision Science
Introduction: Convergence insufficiency is a common binocular vision condition that can cause symptoms when reading or doing close work. While there is literature investigating neural activation during disparity vergence in subjects with convergence insufficiency, previous literature has not examined neural activation in convergence insufficiency isolating the components of convergence: accommodative, proximal and disparity vergence. The purpose of this current study is to investigate the blood oxygenation level dependent (BOLD) signal during a functional magnetic resonance imaging (fMRI) scan during accommodative, proximal, and disparity vergence tasks.
Methods: Adult subjects (n=6, mean age 23.3 years) with convergence insufficiency (exophoria at least 4 prism diopters greater at near than at distance, receded near point of convergence of 6cm or greater, and insufficient positive fusional vergence). Eligible subjects underwent fMRI scanning that included paradigms stimulating accommodative, proximal, and disparity vergence.
Results: Accommodative convergence stimulated regions in the frontal (superior frontal, middle frontal, and precentral gyri), parietal (precuneus, postcentral gyrus), and temporal (middle temporal and inferior temporal gyri) lobes. Proximal convergence stimulated regions in the frontal (superior frontal gyrus), parietal (precuneus, angular gyrus), and temporal (superior temporal gyrus) lobes. Disparity convergence stimulated regions in the occipital lobe.
Conclusion: In this subject cohort, there were overlapping areas of activation (in the frontal, parietal, and temporal lobes) observed during accommodative and proximal convergence tasks, while the disparity vergence activation was confined to the occipital lobe. Areas that have been previously linked to convergence, such as the dorsolateral prefrontal cortex, posterior parietal cortex, parietal eye field, frontal and supplementary eye fields, and occipital lobe were observed to be activ (open full item for complete abstract)
Committee: Kulp Marjean (Advisor); Fogt Nicklaus (Advisor); Toole Andrew (Committee Member); Earley Michael (Committee Member)
Subjects: Health; Neurosciences; Ophthalmology