Bachelor of Science (BS), Ohio University, 0, Translational Health
Cardiovascular disease is the major cause of mortality globally1, and the negative relationship between body mass index (BMI) and cardiovascular risk status is well-established2. The purpose of this study was to examine the relationship between BMI and cardiac disease risk factors in a sample of inhabitants of towns near Lima, Peru. This research hopes to give insight into the degree to which the Peruvian population studied requires an intervention for diet, BMI, and CVD, and how to make such an intervention culturally appropriate.
The biomarkers of glycated hemoglobin (HbA1c)3, systolic and diastolic blood pressure (SBP and DBP, respectively)4,5, triglycerides (TG)6,7,8, total cholesterol (TC)9,10, high- and low-density lipoproteins (HDL and LDL, respectively)11,12 were selected because of their reliability in measuring cardiovascular risk13,14. In this observational study, progressively higher BMI was associated with some abnormal cardiometabolic variables, but not with all variables measured in this study, which conflicts with some prior findings. Higher SBP, DBP, TG, and TC/HDL averages were found in this study to a statistically significant degree. This data confirms prior findings when it comes to blood pressure, TG, and TC/HDL ratios, but not for HbA1c, LDL, TC, or HDL. Because of the lack of significant relationship found between BMI group and all cardiometabolic variables, weight stigma may be, or should be, less in the population studied in comparison to populations with a more definitive relationship between BMI group and all variables. Because abnormalities in each of these cardiometabolic variables is linked to CVD, interventions aimed at reducing body weight to control blood pressure, TG, and TC/HDL to ultimately reduce risk of CVD may be beneficial for this population. Further studies are needed to better understand if the absence of significant correlations between BMI group and HbA1c, LDL, TC, and HDL in this study are the result of population g (open full item for complete abstract)
Committee: David Drozek Dr. (Advisor); Cheryl Howe Dr. (Advisor)
Subjects: Health Sciences; Medicine