Master of Science in Engineering, University of Akron, 2020, Mechanical Engineering
Studying human brains and spinal cords, or many other complex body parts for that matter, come with great challenges and risks when hoping to get accurate data, hopefully in real-time, in vivo, as opposed to in vitro or from a corpse. Of even more interest, are diseased members, since they possess unique traits that shine significant light into the medical community to help understand and treat countless disorders and pathologies. Having this information greatly improves the quality of life for the afflicted, but not to mention, the whole human race. Of particular interest here, is the cerebrospinal fluid flow, a water-like substance, that encases the spinal cord and pulses in and out of the brain's intracranial spaces. Upon entrance into the brain cavity from the spinal cord, it first encounters the cerebellum, the posterior lobes at the bottom of the brain. A lot of studies have been done, in vivo and in vitro, to understand its impact on the movement of the cerebellum, specifically in relation to a Chiari malformation which is characterized by herniation of the cerebellar tonsils. Pahlavian et al shows data from magnetic resonance imaging where the cerebellum of healthy patients moves approximately 100 microns. The work herein uses numerical software tools to hypothesize the cause of the cerebellum's movement. Sources vary widely about the actual material properties of the spinal cord and brain. But with the later data found from Klatt et al, estimates show material elasticity on the order of 1 kPa. With said material elasticity, numerical studies here concluded the cerebellum moves approximately 200 microns. Considering the broad variance among scientists about human tissue elasticities, fluid substance properties, geometry, etc., this was very close to Pahlavian's conclusion, thus fruitful. Two main contributors can lead to cerebellum movement, pressure and wall shear. It was determined from these numerical studies that pressure is the main contrib (open full item for complete abstract)
Committee: Francis Loth (Advisor); Sergio Felicelli (Committee Member)
Subjects: Biomechanics; Biomedical Engineering; Engineering; Fluid Dynamics; Mechanical Engineering