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Characterization of Skeletal Muscle Antibodies in Patients with Autoimmune Rippling Muscles and Myasthenia Gravis

Watkins, Thomas C.
http://rave.ohiolink.edu/etdc/view?acc_num=ysu997728299

Abstract Details

2001, Master of Science in Biological Sciences, Youngstown State University, Department of Biological Sciences and Chemistry.
Rippling muscle disease has been previously described by Torbergsen, as a rare autosomal dominant condition characterized by: muscle stiffness after resting, localized mounding of muscle after resting and electrically silent wave like contractions after stretching (i.e. rippling muscles). In 1990 Ansevin described a patient displaying electrically silent rippling muscles with no evidence of Myasthenia gravis. In 1995 the patient returned for treatment for myasthenia gravis (MG). At the time of treatment for MG the rippling muscles were absent. It was theorized that rippling muscles, in this patient, were the result of an autoimmune condition related to the one that brought on the MG. We have examined serum obtained from this patient with active rippling symptoms and when the rippling symptoms had abated, by western blotting. We have also examined serum obtained from two other patients with rippling muscles and MG. Results indicate that high and intermediate molecular weight antigens in skeletal muscle are recognized by autoantibodies in patients with rippling muscles, which are not present in patients with myasthenia gravis alone. The data suggest autoantibodies may be binding to stretch activated channel proteins causing the symptoms of rippling muscle.
Gary Walker (Advisor)
79 p.
Biology, General
Rippling muscle; Myasthenia gravis

Recommended Citations

Citations

  • Watkins, T. C. (2001). Characterization of Skeletal Muscle Antibodies in Patients with Autoimmune Rippling Muscles and Myasthenia Gravis [Master's thesis, Youngstown State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ysu997728299

    APA Style (7th edition)

  • Watkins, Thomas. Characterization of Skeletal Muscle Antibodies in Patients with Autoimmune Rippling Muscles and Myasthenia Gravis. 2001. Youngstown State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ysu997728299.

    MLA Style (8th edition)

  • Watkins, Thomas. "Characterization of Skeletal Muscle Antibodies in Patients with Autoimmune Rippling Muscles and Myasthenia Gravis." Master's thesis, Youngstown State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ysu997728299

    Chicago Manual of Style (17th edition)

ysu997728299
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© 2001, all rights reserved.
This open access ETD is published by Youngstown State University and OhioLINK.