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Central serotonergic modulation of heart rate in Aplysia Californica

Fulton, Rita
http://rave.ohiolink.edu/etdc/view?acc_num=ysu997103962

Abstract Details

1998, Master of Science in Biological Sciences, Youngstown State University, Department of Biological Sciences and Chemistry.
Studies have shown that sensitization is mediated in Aplysia californica by serotonin. This process, which causes both short-term and long-term enhancement of defensive behaviors such as gill withdrawal or tail withdrawal, can be mimicked by the application of serotonin to the nervous system. However, the cardiovascular response to sensitization has received little attention. In a previous study Litowitz demonstrated that in vitro heart rate increased immediately following sensitizing stimulation and remained elevated for at least 90 minutes (1994). This study explores the hypothesis that serotonin acts as a neuromodulator which promotes sensitization of heart rate, and when applied to the nervous system, duplicated the cardiovascular response produced by sensitizing noxious stimuli. In this experiment, the cardiovascular response to serotonin was monitored in an in vitro preparation. Heart rate was recorded following three sequential application of serotonin to the head ganglia (5x10 -5 M or 5.10 -6 M). Significant short-term increases in heart rate lasting 10 minutes were observed after each application of 5x10- 5 M serotonin. These results indicate that serotonin, acting at the central nervous system, can promote short-term enhancement of cardiovascular function.
Johanna Krontiris-Litowitz (Advisor)
52 p.
Biology, General
Aplysia Californica; serotonin; cardiovascular function

Recommended Citations

Citations

  • Fulton, R. (1998). Central serotonergic modulation of heart rate in Aplysia Californica [Master's thesis, Youngstown State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ysu997103962

    APA Style (7th edition)

  • Fulton, Rita. Central serotonergic modulation of heart rate in Aplysia Californica. 1998. Youngstown State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ysu997103962.

    MLA Style (8th edition)

  • Fulton, Rita. "Central serotonergic modulation of heart rate in Aplysia Californica." Master's thesis, Youngstown State University, 1998. http://rave.ohiolink.edu/etdc/view?acc_num=ysu997103962

    Chicago Manual of Style (17th edition)

ysu997103962
628
© 1998, all rights reserved.
This open access ETD is published by Youngstown State University and OhioLINK.