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Asma FINAL 5 2 2022 with cert.pdf (5.49 MB)

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Electrochemically Regulated Polyelectrolyte Complex for Smart Wound Dressings

Allababdeh, Asma S.
http://rave.ohiolink.edu/etdc/view?acc_num=ysu1651585819454702

Abstract Details

2022, Master of Science in Engineering, Youngstown State University, Department of Civil/Environmental and Chemical Engineering.
Precise control over the release of drugs from wearable bioelectronic devices on wound sites, such as quantity and timing, is highly desirable in order to optimize wound treatment. The aim of this study is to obtain and characterize an electro-responsive ferrocene-chitosan/alginate polyelectrolyte complex (PEC) hydrogel that can be used as a smart wound dressing. First, chitosan/alginate PEC hydrogel was obtained as a control and characterized in terms of chemical properties and drug release kinetics. Natural chitosan (CHI) was chemically conjugated with ferrocene (Fc) moieties to create Fc-CHI. The Fc-CHI was interacted with alginate (ALG) to form Fc-CHI/ALG PEC through electrostatic interaction. The turbidity test was performed to find the optimum ratio between the Fc-CHI and ALG, thus the stoichiometric PEC hydrogel. The PEC hydrogel was characterized by Attenuated Total Reflection Fourier Transform Infrared Spectroscopy (ATR-FTIR), Scanning Electron Microscopy (SEM), Energy Dispersive X-ray Spectrometer (EDS), in addition to the swelling behavior and gel content tests. Comparative analysis of the ATR-FTIR spectra of CHI, Fc-CHI, ALG, and their mixtures indicated the formation of a polyelectrolyte complex. The SEM images showed the porosity of the PEC. The EDS analysis proved the incorporation of the Fc into the CHI by the appearance of the Fc peaks in the analysis. The PEC hydrogel showed a comparative swelling percentage to be 4400% and also showed excellent stability, proved by almost 100% gel content after incubation in phosphate buffer saline (PBS) solution. To demonstrate the drug delivery potential of the developed PEC-based wound dressing, fluorescence (FITC) and FITC-Dextran were used as model drugs. First, the drug loading and release kinetics of the PEC were studied in solution. In three days, about 83% and 61% were released of the FITC, and FITC-Dextran, respectively in PBS solution. Secondly, the drug release properties on the phantom skin surface (agarose gel) were investigated using a custom-made electrical stimulus setup incorporated with fluorescence microscopy. The release of the model drugs on the surface was tested in passive (no electrical stimulus) and active (with electrical stimulus) manners. The PEC hydrogels showed an electro-responsivity represented by increasing the intensity of the model drugs that diffused through the agarose gel under the electric stimulus. The diffusion coefficients for different drug models were estimated by analyzing images obtained after a time series of acquisition. Based on the results, the developed Fc-CHI/ALG PEC hydrogel is prone to be an enhanced drug release upon the electrical stimulus, compared to the CHI/ALG PEC hydrogel. This indicates the presence of Fc may be able to increase the electro-osmosis and develop the enhanced stress gradient in the PEC hydrogel followed by the spontaneous drug release. The developed PEC hydrogel may be integrated with bioelectronic devices such as the smart bandage.
Byung-Wook Park, PhD (Advisor)
Pedro Cortes, PhD (Committee Member)
Holly Martin, PhD (Committee Member)
92 p.
Biomedical Engineering; Chemical Engineering; Materials Science
Drug delivery; Polyelectrolyte complex; Controlled release; Smart wound dressing

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Citations

  • Allababdeh, A. S. (2022). Electrochemically Regulated Polyelectrolyte Complex for Smart Wound Dressings [Master's thesis, Youngstown State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1651585819454702

    APA Style (7th edition)

  • Allababdeh, Asma. Electrochemically Regulated Polyelectrolyte Complex for Smart Wound Dressings. 2022. Youngstown State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ysu1651585819454702.

    MLA Style (8th edition)

  • Allababdeh, Asma. "Electrochemically Regulated Polyelectrolyte Complex for Smart Wound Dressings." Master's thesis, Youngstown State University, 2022. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1651585819454702

    Chicago Manual of Style (17th edition)

ysu1651585819454702
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© 2022, all rights reserved.
This open access ETD is published by Youngstown State University and OhioLINK.