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Biomechanical Simulation of Cardiovascular Implantable Electronic Device Leads with Residual Properties

Salih, Anmar Mahdi
http://rave.ohiolink.edu/etdc/view?acc_num=wright1714506706310622

Abstract Details

2024, Doctor of Philosophy (PhD), Wright State University, Engineering PhD.
Implantable leads used in pacemakers, defibrillators, and cardiac resynchronization therapy are designed for in-vivo applications, yet their longevity is inevitably shaped by the conditions within the human body. The mechanical behavior of these leads can be affected over time, necessitating the evaluation of their residual properties. Two main insulators, silicone, and polyurethane are commonly used for the outer insulation of cardiac leads. Understanding the long-term performance of these insulators is crucial for ensuring the reliability and safety of cardiac implantable devices. The research aims to assess the long-term mechanical properties and performance of implantable leads utilized in cardiovascular implantable electronic devices (CIEDs), which are subjected to the in-vivo environment with finite lifespans. Utilizing more than 300 samples obtained from the Wright State University Anatomical Gift Program. Tests were conducted according to ASTM standard D 1708-02a and ASTM Standard D 412-06a using the Test Resources Q series system. Electromagnetic interference (EMI) from electric vehicles on CIEDs, particularly Subcutaneous Implantable Cardioverter-Defibrillators (S-ICDs) were quantified within a Tesla Model 3. SolidWorks and MIMICS 25.0 were used for three-dimensional heart modeling, and were developed with CIED leads inside the heart for finite element analysis. ANSYS Workbench 2022R1 was utilized for simulating cardiac leads behavior inside the heart with specific residual properties, and used computational simulations to predict lead performance. This research found silicone insulation to show some degradation in mechanical properties after 94 months of in-vivo environment, and polyurethane insulation demonstrated consistent performance without significant degradation after 108 months of in-vivo exposure. The proposed mechanical testing and FEM provide an insight into the durability and performance of different insulation materials, and how these materials behave over time when exposed to physiological conditions within the body. From this perspective, we can enhance the durability of CIED leads, potentially extending their lifespan. This research holds promises in guiding future advancements in CIED lead design and ultimately enhancing patient outcomes in the field of cardiac rhythm management.
Tarun Goswami, D.Sc. (Advisor)
Abdul Wase, MBBS (Committee Member)
Vic Middleton, Ph.D. (Committee Member)
Jaime E. Ramirez-Vick, Ph.D. (Committee Member)
543 p.
Biomedical Engineering
Polyurethane; Silicone; Lead Insulation; ICD leads; Left ventricle leads; Failure analysis; Finite Element; CIED leads insulation; 3D modeling; In-vivo environment; Electric Vehicle; EV; EMI; EMF; Subcutaneous ICD; S-ICD; Tesla

Recommended Citations

Citations

  • Salih, A. M. (2024). Biomechanical Simulation of Cardiovascular Implantable Electronic Device Leads with Residual Properties [Doctoral dissertation, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1714506706310622

    APA Style (7th edition)

  • Salih, Anmar. Biomechanical Simulation of Cardiovascular Implantable Electronic Device Leads with Residual Properties. 2024. Wright State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1714506706310622.

    MLA Style (8th edition)

  • Salih, Anmar. "Biomechanical Simulation of Cardiovascular Implantable Electronic Device Leads with Residual Properties." Doctoral dissertation, Wright State University, 2024. http://rave.ohiolink.edu/etdc/view?acc_num=wright1714506706310622

    Chicago Manual of Style (17th edition)

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© 2024, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.