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Impaired β-Cell Neogenesis in a Mouse Model of Metabolic Syndrome

Alshammari, Modhi Abdullah
http://orcid.org/0000-0001-6122-1999
http://rave.ohiolink.edu/etdc/view?acc_num=wright165364831884485

Abstract Details

2022, Master of Science (MS), Wright State University, Pharmacology and Toxicology.
Pancreatic islet β-cell plays an essential role in insulin release and hence glucose homeostasis. The maintenance of glucose homeostasis depends on β-cell ability to cope with enough insulin to fulfill metabolic and physiological demands. Adequate insulin release is the result of highly complex and dynamic interplays between acute changes in β- cell electrical activity, exocytosis and chronic adaptations in cellular function, volume, mass and proliferation. All of this appears modulated, to some extent, by the functional presence of Slc12a2 symporters, also known as Na+K+2Cl– cotransporter-1 (Nkcc1), which accumulates intracellular Cl– above its electrochemical equilibrium. Recent studies from our laboratory showed that mice lacking Nkcc1 in β-cell (Nkcc1βKO) develop a cluster of metabolic phenotypes reminiscent of the metabolic syndrome i.e., hyperglycemia, hyperinsulinemia, glucose intolerance, insulin resistance, steatohepatitis and overweight. The present study is aimed at determining the potential relationship between those phenotypes and pancreas morphometric parameters including islet size, β-cell number, volume, mass and neogenesis. The results presented here indicate that elimination of Nkcc1 from β-cell negatively impact those parameters, even before the onset of overweight and its metabolic complications. Therefore, we propose that Nkcc1 plays a potential causative role in the development of metabolic syndrome.
Mauricio Di Fulvio, Ph.D. (Advisor)
Courtney Sulentic, Ph.D. (Committee Member)
Khalid Elased, Pharm.D., Ph.D. (Committee Member)
93 p.
Biology; Pharmacology
Pancreatic islet β-cell; β-cell; glucose homeostasis; insulin; metabolic syndrome; neogenesis; Nkcc1

Recommended Citations

Citations

  • Alshammari, M. A. (2022). Impaired β-Cell Neogenesis in a Mouse Model of Metabolic Syndrome [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright165364831884485

    APA Style (7th edition)

  • Alshammari, Modhi. Impaired β-Cell Neogenesis in a Mouse Model of Metabolic Syndrome. 2022. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright165364831884485.

    MLA Style (8th edition)

  • Alshammari, Modhi. "Impaired β-Cell Neogenesis in a Mouse Model of Metabolic Syndrome." Master's thesis, Wright State University, 2022. http://rave.ohiolink.edu/etdc/view?acc_num=wright165364831884485

    Chicago Manual of Style (17th edition)

wright165364831884485
239
© 2022, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.