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Noninvasive Blood Flow and Oxygenation Measurements in Diseased Tissue

Rinehart, Benjamin S.
http://orcid.org/0000-0002-8212-6883
http://rave.ohiolink.edu/etdc/view?acc_num=wright1639414818597832

Abstract Details

2021, Doctor of Philosophy (PhD), Wright State University, Engineering PhD.
The research presented in this dissertation focused on the application of optical imaging techniques to establish blood flow and oxygen saturation as effective biomarkers for two disease cases, Autism Spectrum Disorder (ASD) and Huntington’s Disease (HD). The BTBR mouse model of ASD was utilized to validate measurements of cerebral blood flow and oxygenation as biomarkers for autism. The R6/2 mouse model of juvenile HD was utilized to validate measurements of skeletal muscle blood flow following tetanic muscle contractions induced by electrical nerve stimulation. Next, a noncontact, camera-based system to measure blood flow and oxygen saturation maps was implemented to improve upon the previous HD mouse results by providing spatial heterogeneity in a wild-type mouse model. Finally, translational research was performed to validate a research design conducting concurrent grip strength force and skeletal muscle blood flow and oxygenation measurements in a healthy human population that will be used to establish HD biomarkers in humans in future clinical applications.
Ulas Sunar, Ph.D. (Advisor)
Andrew Voss, Ph.D. (Committee Member)
Sandra Kostyk, M.D., Ph.D. (Committee Member)
Tarun Goswami, Ph.D. (Committee Member)
Mark Rich, Ph.D. (Committee Member)
117 p.
Biomedical Engineering; Biomedical Research; Medical Imaging; Optics
optical imaging; huntington's disease; autism; laser speckle contrast imaging; biomedical engineering; spatial frequency domain imaging; diffuse correlation spectroscopy; spectroscopy; in vivo spectroscopy; blood flow; blood oxygen saturation

Recommended Citations

Citations

  • Rinehart, B. S. (2021). Noninvasive Blood Flow and Oxygenation Measurements in Diseased Tissue [Doctoral dissertation, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1639414818597832

    APA Style (7th edition)

  • Rinehart, Benjamin. Noninvasive Blood Flow and Oxygenation Measurements in Diseased Tissue. 2021. Wright State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1639414818597832.

    MLA Style (8th edition)

  • Rinehart, Benjamin. "Noninvasive Blood Flow and Oxygenation Measurements in Diseased Tissue." Doctoral dissertation, Wright State University, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=wright1639414818597832

    Chicago Manual of Style (17th edition)

wright1639414818597832
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© 2021, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.