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KINETICS AND PASSIVE PROTECTION EFFICACY INDUCED BY PURIFIED AVA HUMAN IMMUNOGLOBULIN G IN RABBITS AGAINST A Bacillus anthracis AEROSOL CHALLENGE

Plahovinsak, Jennifer Lee
http://rave.ohiolink.edu/etdc/view?acc_num=wright1166813637

Abstract Details

2006, Master of Science (MS), Wright State University, Pharmacology and Toxicology.
The present study was conducted to determine the half-life, assess the toxicity, and passive protection efficacy of purified immunoglobulin G (IgG) from Anthrax Vaccine Adsorbed (AVA) vaccinated human donors. Half-life determinations were calculated from the reportable values obtained using the anti-PA ELISA assay and the Centers for Disease Control’s (CDC) “ELISA for Windows” software. For toxicity evaluations animals were observed clinical for one hour post administration and for 14-days post-treatment. The protection efficacy was determined based upon the mortality results from a lethal Bacillus anthracis aerosol challenge. While no protection was achieved in this delayed exposure scenario, the study yielded valuable kinetics data for use in future research.
Robert Casillas (Advisor)
75 p.
Biology, General
ELISA; AIG; anti-PA; Na¿¿¿¿ve; IgG; LOQ; Diluent

Recommended Citations

Citations

  • Plahovinsak, J. L. (2006). KINETICS AND PASSIVE PROTECTION EFFICACY INDUCED BY PURIFIED AVA HUMAN IMMUNOGLOBULIN G IN RABBITS AGAINST A Bacillus anthracis AEROSOL CHALLENGE [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1166813637

    APA Style (7th edition)

  • Plahovinsak, Jennifer. KINETICS AND PASSIVE PROTECTION EFFICACY INDUCED BY PURIFIED AVA HUMAN IMMUNOGLOBULIN G IN RABBITS AGAINST A Bacillus anthracis AEROSOL CHALLENGE. 2006. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1166813637.

    MLA Style (8th edition)

  • Plahovinsak, Jennifer. "KINETICS AND PASSIVE PROTECTION EFFICACY INDUCED BY PURIFIED AVA HUMAN IMMUNOGLOBULIN G IN RABBITS AGAINST A Bacillus anthracis AEROSOL CHALLENGE." Master's thesis, Wright State University, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=wright1166813637

    Chicago Manual of Style (17th edition)

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© 2006, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.