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ucin998323664.pdf (537.5 KB)
ETD Abstract Container
Abstract Header
Improvements in Pamam Dendrimer Synthesis
Author Info
Dotson, Michael Edward
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=ucin998323664
Abstract Details
Year and Degree
2001, PhD, University of Cincinnati, Arts and Sciences : Chemistry.
Abstract
PAMAM dendrimers have been synthesized using two separate acrylamide monomer compounds, (2-acryloylamino-ethyl)-carbamic acid tert-butyl ester (1) and N-cyanomethyl-acrylamide (18). These monomer units allow for facile synthesis of PAMAM dendrimers with decreased opportunity of defects. Zero and first generations dendrimers have been synthesized with compound 1 and zero through second generation dendrimers have been synthesized with compound 18. Various amine-terminated compounds were used as initiator cores from which the dendrimers were grown. Dendrimers were also grown using 3-[(2-tert-butoxycarbonylamino-ethyl)-(2-methoxycarbonyl-ethyl)-amino]-propionic acid methyl ester (9). After selective deprotection of this compound, normal amino acid coupling procedures were used to produce the next higher half-generation dendrimer.
Committee
Prof. Allan Pinhas (Advisor)
Prof. William Heineman (Other)
Prof. H. Halsall (Other)
Prof. R. Wilson (Other)
Subject Headings
Chemistry, Organic
Keywords
PAMAM DENDRIMERS
;
ACRYLAMIDE
;
GENERATION DENDRIMERS
;
MICHAEL ADDITION
;
TOMALIA
Recommended Citations
Refworks
EndNote
RIS
Mendeley
Citations
Dotson, M. E. (2001).
Improvements in Pamam Dendrimer Synthesis
[Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin998323664
APA Style (7th edition)
Dotson, Michael.
Improvements in Pamam Dendrimer Synthesis.
2001. University of Cincinnati, Doctoral dissertation.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=ucin998323664.
MLA Style (8th edition)
Dotson, Michael. "Improvements in Pamam Dendrimer Synthesis." Doctoral dissertation, University of Cincinnati, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin998323664
Chicago Manual of Style (17th edition)
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Document number:
ucin998323664
Download Count:
1,627
Copyright Info
© 2001, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.