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Full text release has been delayed at the author's request until August 03, 2026

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Predicting Peak Oxygen Uptake as a Cardiopulmonary Function Marker: Assessing Disease Impact in Pectus Excavatum

Parrado, Raphael
http://orcid.org/0000-0003-0388-3948
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1721397904897417

Abstract Details

2024, MS, University of Cincinnati, Medicine: Clinical and Translational Research.
Background: Beyond cosmesis, the impact of pectus excavatum on cardiopulmonary function remains controversial. Cardiopulmonary exercise testing (CPET) is often performed to assess functional impact in this patient population. One well-established measure of functional capacity is the percent predicted peak oxygen uptake (VO2). We sought to evaluate the association of predicted peak VO2 extremes (<80% and >95%) with patient and pectus characteristics to better delineate its applicability as a marker of disease or indication for treatment. Methods: A single-center retrospective study was conducted, including patients diagnosed with pectus excavatum between 2017 and 2022. Patient demographics, symptoms, imaging, and cardiopulmonary function were evaluated. Results: Of 678 patients who underwent CPET, 444 were categorized into low <80% predicted (n=257) and high >95% predicted (n=187) VO2 groupings. Patients were mean age 15.3 years, predominantly male (77%), white race (98%), and 594 (75%) were symptomatic. In univariate analysis, male patients, lower long volumes (FVC/FEV1), and severe pectus deformity (Haller and correction index) were related to worse peak VO2 (p<0.05). After adjustment, older patients (>18 years), males, and higher correction index were significantly associated with lower percent predicted peak VO2 (p<0.05). There was no association with symptoms in both univariate and multivariate analyses. Conclusion: In patients with pectus excavatum, peak VO2 differs according to age and gender; however, it also decreases with increased severity of the defect. Symptoms, however, are not predictive. The percentage of predicted peak VO2 may be a helpful indicator of impaired cardiopulmonary function in patients with severe pectus deformities. Further studies are warranted to assess the impact of repair.
Patrick Ryan, Ph.D. (Committee Chair)
Todd Jenkins, Ph.D. (Committee Member)
Rebeccah Brown (Committee Member)
11 p.
Surgery
Pectus Excavatum; Cardiopulmonary Testing; Cardiopulmonary Function; Exercise Testing

Recommended Citations

Citations

  • Parrado, R. (2024). Predicting Peak Oxygen Uptake as a Cardiopulmonary Function Marker: Assessing Disease Impact in Pectus Excavatum [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1721397904897417

    APA Style (7th edition)

  • Parrado, Raphael. Predicting Peak Oxygen Uptake as a Cardiopulmonary Function Marker: Assessing Disease Impact in Pectus Excavatum. 2024. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1721397904897417.

    MLA Style (8th edition)

  • Parrado, Raphael. "Predicting Peak Oxygen Uptake as a Cardiopulmonary Function Marker: Assessing Disease Impact in Pectus Excavatum." Master's thesis, University of Cincinnati, 2024. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1721397904897417

    Chicago Manual of Style (17th edition)

ucin1721397904897417
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This open access ETD is published by University of Cincinnati and OhioLINK.