Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List

Full text release has been delayed at the author's request until April 25, 2026

ETD Abstract Container

Abstract Header

Real world adherence to biologic therapy in severe asthma

Rose, Steven
http://orcid.org/0009-0004-0083-5945
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1712918064366132

Abstract Details

2024, MS, University of Cincinnati, Medicine: Clinical and Translational Research.
Background and Objectives: Patients with severe asthma are a small proportion of patients with asthma, but make up a substantial part of the costs, morbidity, and mortality of pediatric asthma. The use of injectable biologic medications has been shown to improve asthma symptom burden, reduce exacerbations and improve lung function in children with severe asthma in several clinical trials. However, little is known about adherence to biologic medications in pediatrics. The objective of this study is to describe adherence to biologic medications in pediatric asthma and evaluate risk factors related to adherence. The relationship of biologic therapy adherence and asthma outcomes will also be examined. Methods: A retrospective medical chart review was performed of patients with severe asthma treated at Cincinnati Children’s Hospital Medical Center who had been prescribed biologic therapy. Medication administration information was extracted and the rate of adherence was calculated over the first 6 months and 12 months of therapy. Adherence was characterized by medication type, dosing frequency, demographic factors, and atopic features. The effect of biologic therapy on asthma related outcomes was analyzed using Wilcoxon signed-rank test and the relationship of adherence to asthma related outcomes was analyzed using logistic regressions. Results: Patients demonstrated 75% adherence to biologic therapies during the first 6 months of therapy (standard deviation (SD) = 25.3%) and 63% adherence over the first 12 months (SD = 29.0%) of treatment. Differences in adherence at 6 months were observed between types of biologic therapies with benralizumab having the highest rate of adherence (85.9% (SD= 17.0%) over 6 months, 79.5% (SD= 26.7%) over 12 months). There were no significant differences in adherence at 6 or 12 months based on age, sex, race, ethnicity, number of allergies, distance to the medical center from home, or eosinophil count. Asthma outcomes were improved over the year that patients were on biologic therapy such that asthma exacerbation rate decreased by an average rate of 0.9 (SD=2.0) per year, oral steroid courses decreased by 0.9 (SD=2.0) per year, and hospitalizations and ED visits decreased by 0.65 (SD=1.5) per year. However, these decreases were not significantly associated with adherence. Conclusions: Patients with severe asthma treated with biologic therapy demonstrated higher rates of adherence to asthma biologic medications than typically is demonstrated for inhaled corticosteroid adherence. Biologic therapies improve asthma related health outcomes, but this was not impacted by adherence rate. There is a differential adherence based on type of medication, potentially related to administration mechanisms. Thus, the method and frequency of administration should be considered when selecting a biologic treatment.
Patrick Ryan, Ph.D. (Committee Chair)
Rachelle Ramsey, Ph.D. (Committee Member)
Md Monir Hossain, Ph.D. (Committee Member)
Theresa Guilbert (Committee Member)
12 p.
Medicine
Asthma; biologic; pediatric

Recommended Citations

Citations

  • Rose, S. (2024). Real world adherence to biologic therapy in severe asthma [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1712918064366132

    APA Style (7th edition)

  • Rose, Steven. Real world adherence to biologic therapy in severe asthma. 2024. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1712918064366132.

    MLA Style (8th edition)

  • Rose, Steven. "Real world adherence to biologic therapy in severe asthma." Master's thesis, University of Cincinnati, 2024. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1712918064366132

    Chicago Manual of Style (17th edition)

ucin1712918064366132
© 2024, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.