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The Immunotherapeutic Approach to Glioblastoma Multiforme

Ahad, Leena
http://orcid.org/0000-0002-5695-8344
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1712915665994219

Abstract Details

2024, MS, University of Cincinnati, Medicine: Cancer and Cell Biology.
Glioblastoma multiforme poses significant treatment challenges, attributed to its distinctive characteristics and immune evasion mechanisms, and carries a grim prognosis despite advancements in therapy. Therefore, rigorous efforts are necessary to uncover additional therapies or other unconventional strategies. Recently, immunotherapies have gained significant traction due to their success in certain malignancies. Immunotherapies use the host's immune system to enhance the ability to combat cancer. These therapies have been in development for over 100 years, and many of them are currently under investigation for treating Glioblastoma multiforme in preclinical and clinical studies. Immunotherapies include antibody therapies, including immune checkpoint blockade, adoptive T cell therapies, cytokine therapies, cancer vaccines, and oncolytic viruses. A deeper understanding of the origins of immunotherapy, immune system dynamics in response to cancer, immune evasion mechanisms of glioblastoma, and the various immunotherapeutic strategies may facilitate the development of novel and effective treatment strategies for glioblastoma. Here, we review the different immunotherapeutic approaches and propose possible combinatory strategies.
Qing Lu, Ph.D. (Committee Chair)
David Plas, Ph.D. (Committee Member)
Biplab DasGupta, Ph.D. (Committee Member)
David Haslam, M.D. (Committee Member)
126 p.
Oncology
Glioblastoma multiforme; Immunotherapy; GBM; Immune Evasion; Cancer; Innate and adaptive immune response to cancer

Recommended Citations

Citations

  • Ahad, L. (2024). The Immunotherapeutic Approach to Glioblastoma Multiforme [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1712915665994219

    APA Style (7th edition)

  • Ahad, Leena. The Immunotherapeutic Approach to Glioblastoma Multiforme. 2024. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1712915665994219.

    MLA Style (8th edition)

  • Ahad, Leena. "The Immunotherapeutic Approach to Glioblastoma Multiforme." Master's thesis, University of Cincinnati, 2024. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1712915665994219

    Chicago Manual of Style (17th edition)

ucin1712915665994219
114
© 2024, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.