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Full text release has been delayed at the author's request until December 09, 2025

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Carbon Quantum Dots for Photothermal Nucleic Acid Amplification

Balou, Salar
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1703173390729157

Abstract Details

2023, PhD, University of Cincinnati, Engineering and Applied Science: Chemical Engineering.
The research presented in this dissertation focuses on the remarkable photothermal properties and application potential of carbon quantum dots (CQDs), specifically red graphene quantum dots (RGQDs). These nanomaterials exhibit promising photothermal performance across various applications, with a meta-analysis revealing the impact of synthesis protocols, precursor types, and numerous factors on their performance. Despite significant progress, challenges persist in achieving the desired functionality compared to metallic competitors. Strategies and future research directions are outlined, emphasizing the need for mechanistic understanding, a model for parameter optimization, and the exploration of new applications. Therefore, our work delves into the synthesis and characterization of Cyan, Green-Yellow, and Red Color Emissive Carbon Dots (CDs). The study uncovers the intricate relationship between synthesis conditions and the resulting chemical and optical properties. The role of heteroatoms (O and N) in fluorescence emission characteristics is elucidated, offering opportunities for tailored optical properties. In the context of photothermal heating, a comprehensive analysis involving these carbon dots is presented, showcasing the impressive photothermal conversion efficiency (PCE) of RGQDs. The research investigates factors affecting the PCE of CDs and provides a mechanistic understating of their photothermal conversion as promised. The compatibility of RGQDs in Polymerase Chain Reaction (PCR) is explored, revealing their impact on DNA condensation which opens the path for potential applications in molecular biology and nanotechnology research. Innovative approaches are proposed such as the RGQDs/Hydrogel setup that offers the utilization of RGQDs as photothermal heating agents to develop a cost-effective, portable, and efficient solution for in Nucleic Acid Amplifications (NAAs). Customer interviews and a comprehensive analysis of primary and secondary discoveries were conducted to explore the real-world applications of our system.
Aashish Priye, Ph.D. (Committee Chair)
Benjamin Yavitt, Ph.D. (Committee Member)
Vesselin Shanov, Ph.D. (Committee Member)
Jason Heikenfeld, Ph.D. (Committee Member)
128 p.
Chemical Engineering
Carbon Quantum Dots; Nanoparticles; Photothermal Nanoparticles

Recommended Citations

Citations

  • Balou, S. (2023). Carbon Quantum Dots for Photothermal Nucleic Acid Amplification [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1703173390729157

    APA Style (7th edition)

  • Balou, Salar. Carbon Quantum Dots for Photothermal Nucleic Acid Amplification. 2023. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1703173390729157.

    MLA Style (8th edition)

  • Balou, Salar. "Carbon Quantum Dots for Photothermal Nucleic Acid Amplification." Doctoral dissertation, University of Cincinnati, 2023. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1703173390729157

    Chicago Manual of Style (17th edition)

ucin1703173390729157
© 2023, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.