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The Diversity and Functions of Microglia/Macrophages in Neurological Disease and Glioma Microenvironment

Rajagopalan, Shanmuga Priya
http://orcid.org/0000-0003-4096-9740
http://rave.ohiolink.edu/etdc/view?acc_num=ucin166863693692373

Abstract Details

2022, MS, University of Cincinnati, Medicine: Cancer and Cell Biology.
Microglia is the primary brain resident macrophage and is an integral component of brain development and functions including neurogenesis, angiogenesis, and synapse formation. The microglia exhibit spatial and temporal diversity in their morphology and functions. The microglial functions depend on the region and stage of development. Despite the advancement in research on microglia, the diversity profile of the microglia has yet been fully understood. Besides microglia, immune cells in the normal brain also include macrophages like the choroid plexus, meningeal, and perivascular macrophages. The role of microglia and different brain resident macrophages in normal brain physiology, neurological diseases, and brain tumors remains to be poorly defined. As the deadliest immune-privileged brain tumor, glioblastomas are largely treatment-resistant, which is in part due to the immunosuppressive tumor microenvironment. Specifically, the tumor-associated macrophages (TAM) act as a pro- and anti-tumorigenic component in GBM and are emerging as a potential target for developing anti-tumor drugs. Here, we discuss the origin, biomarkers, regulatory factors, and physiology of disease-associated microglia/macrophages. A better understanding of disease-associated microglia/macrophages and tumor microenvironment may facilitate the development of effective treatment strategies for neurodegenerative diseases and brain cancers.
Qing Lu, Ph.D. (Committee Member)
Ty Troutman, Ph.D. (Committee Member)
Ziyuan Guo, Ph.D. (Committee Member)
Theresa Alenghat, V.M.D. Ph.D. (Committee Member)
111 p.
Cellular Biology
Microglia; Brain macrophages; Neurological disease; Glioma; tumor-microenvironment; Tumor associated macrophages

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Citations

  • Rajagopalan, S. P. (2022). The Diversity and Functions of Microglia/Macrophages in Neurological Disease and Glioma Microenvironment [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin166863693692373

    APA Style (7th edition)

  • Rajagopalan, Shanmuga Priya. The Diversity and Functions of Microglia/Macrophages in Neurological Disease and Glioma Microenvironment. 2022. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin166863693692373.

    MLA Style (8th edition)

  • Rajagopalan, Shanmuga Priya. "The Diversity and Functions of Microglia/Macrophages in Neurological Disease and Glioma Microenvironment." Master's thesis, University of Cincinnati, 2022. http://rave.ohiolink.edu/etdc/view?acc_num=ucin166863693692373

    Chicago Manual of Style (17th edition)

ucin166863693692373
148
© 2022, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.