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Vitamin D Insufficiency and its Association with Risk for Dementia

Tallman, Maxwell
http://orcid.org/0000-0003-3036-561X
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1649769573767651

Abstract Details

2022, MPH, University of Cincinnati, Medicine: Epidemiology.
Background. Vitamin D is commonly understood to be involved in the regulation of bone density and calcium homeostasis which also regulate parathyroid hormone activity. Many studies also discuss the impact of vitamin D deficiency on neuropsychological conditions such as depression, multiple sclerosis, and dementia. This study seeks to examine the relationship between age, serum vitamin D levels, and risk for dementia. Methods. This study was a retrospective cohort study of patients seen at the University of Cincinnati Academic Health Center. 21264 subjects contributed to 50268 total observations. Observations were included if they contained serum vitamin D levels, as well as values for predictors of interest such as dementia status, age, race, gender, and UV status at the time of the visit. A mixed methods approach was used to conduct multiple linear regression using vitamin D level as the primary outcome variable, dementia status, age, race, gender, UV status, and an interaction term between dementia status and age. Results and Conclusions. Patients who eventually develop dementia were shown to have reduced vitamin D values compared to their counterparts in the never dementia group. Race, gender, and UV status of the visit were all statistically significant. Belonging to black or African American race, and male gender patient groups contributes to having lower serum vitamin D levels. Age alone was not statistically significant; however, the interaction term between age and dementia group was (t= 3.99, F=15.94, p<0.0001). This supports the hypothesis that the rate of change in serum vitamin D values would be different between patients who go on to develop dementia and those who do not. Of specific interest, mean serum vitamin D values in each group were relatively close to 32 ng/ml of vitamin D which has been reported to be a threshold about which parathyroid hormone activity is modulated. Further research to better understand the role of parathyroid hormone in risk for dementia and other neuropsychiatric illnesses is warranted.
Kelly Brunst, Ph.D. (Committee Member)
Jeffrey Welge, Ph.D. (Committee Member)
Robert Krikorian, Ph.D. (Committee Member)
21 p.
Epidemiology
Vitamin D; Dementia; Vitamin D Insufficiency; Risk for Dementia

Recommended Citations

Citations

  • Tallman, M. (2022). Vitamin D Insufficiency and its Association with Risk for Dementia [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1649769573767651

    APA Style (7th edition)

  • Tallman, Maxwell. Vitamin D Insufficiency and its Association with Risk for Dementia. 2022. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1649769573767651.

    MLA Style (8th edition)

  • Tallman, Maxwell. "Vitamin D Insufficiency and its Association with Risk for Dementia." Master's thesis, University of Cincinnati, 2022. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1649769573767651

    Chicago Manual of Style (17th edition)

ucin1649769573767651
17
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This open access ETD is published by University of Cincinnati and OhioLINK.