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The Design and Characterization of a Piezoelectric PVDF-TrFE Nanofiber Scaffold for Nerve Repair Applications

Wolf, Ann
http://orcid.org/0000-0003-2282-2171
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1649761930398376

Abstract Details

2022, MS, University of Cincinnati, Engineering and Applied Science: Electrical Engineering.
Severe peripheral nerve injuries are currently limited in their available treatment approaches. Standard clinical therapies include the use of nerve grafts or nerve conduits to guide axons across the injury gap, however many of these approaches show variable outcomes in functional recovery, possibly due to a lack of cues directing the nerve regeneration. Polyvinylidene flouride triflouroethylene (PVDF-TrFE) is a piezoelectric polymer that generates electric charge in response to mechanical deformation, and can provide a suitable regenerative microenvironment by imparting electrical stimulation to direct peripheral nervous system cells and function. In this thesis, PVDF-TrFE nanofibrous scaffolds are fabricated through electrospinning and are extensively characterized for their material and electrical properties. Further, the PVDF-TrFE scaffolds are functionalized with decellularized extracellular matrix (dECM), presenting a promising outlook for a piezoelectric biomaterial for tissue engineering.
Leyla Esfandiari, Ph.D. (Committee Member)
Tao Li, Ph.D. (Committee Member)
Greg Harris, Ph.D. (Committee Member)
60 p.
Electrical Engineering
piezoelectric; nerve repair; PVDF

Recommended Citations

Citations

  • Wolf, A. (2022). The Design and Characterization of a Piezoelectric PVDF-TrFE Nanofiber Scaffold for Nerve Repair Applications [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1649761930398376

    APA Style (7th edition)

  • Wolf, Ann. The Design and Characterization of a Piezoelectric PVDF-TrFE Nanofiber Scaffold for Nerve Repair Applications. 2022. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1649761930398376.

    MLA Style (8th edition)

  • Wolf, Ann. "The Design and Characterization of a Piezoelectric PVDF-TrFE Nanofiber Scaffold for Nerve Repair Applications." Master's thesis, University of Cincinnati, 2022. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1649761930398376

    Chicago Manual of Style (17th edition)

ucin1649761930398376
251
© 2022, some rights reserved.Creative Commons License The Design and Characterization of a Piezoelectric PVDF-TrFE Nanofiber Scaffold for Nerve Repair Applications by Ann Wolf is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by University of Cincinnati and OhioLINK.