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Novel Microelectrodes and New Material for Real-Time Electrochemical Detection of Neurotransmitters

Li, Yuxin
http://rave.ohiolink.edu/etdc/view?acc_num=ucin163715413634062

Abstract Details

2021, PhD, University of Cincinnati, Arts and Sciences: Chemistry.
Fast scan cyclic voltammetry (FSCV) has been used for monitoring neurotransmitters real-time in vivo and in vitro over the last several decades and carbon fiber microelectrodes are the standard working electrode to monitor electroactive neurotransmitters. Carbon is an excellent electrode surface because it can be easily modified to change the chemical structure, topology, functionalization, defects, and 3D shape. This dissertation aims to develop novel carbon-based microelectrode surfaces to study fundamental electrode-analyte interactions to inform the development of ultrasensitive electrochemical sensors. Chapter 1 covers the importance of neurotransmitter detection, neurochemical detection methods, and novel carbon nanomaterial design for FSCV detection. Chapter 2, 3 and 4 study the relationship between the carbon microelectrode’s surface structure and their electrochemical behavior. More specifically, Chapter 2 explores the effects of plasma treatment on surface roughness and functionalization of carbon-fiber microelectrodes to enhance purine detection. Chapter 3 introduces different functional groups on carbon fiber and measures their impact on ATP detection with FSCV and Chapter 4 explores the mechanism of fouling resistance by correlating changes in defect sites to degree of fouling resistance. Chapter 5 introduces the concept of incorporating metal nanoparticles on carbon microelectrodes to enhance the sensitivity and catalytic properties for ATP detection. Chapter 6 describes a brand-new material for neurochemical detection: graphene microfibers. Finally, Chapter 7 covers challenges and future directions using graphene to fabricate electrode sensors and addresses the development of improved sensitivity of detection. Overall, my dissertation explores fundamental electrochemical studies on the surface and chemical structures of carbon microelectrodes for neurotransmitter detection. The fundamental studies introduce nanoparticles and graphene-based material designed for neurotransmitter detection and provide not only improvements in sensitivity by improvements in temporal resolution of detection and anti-fouling properties. In conclusion, this work will greatly benefit future design of biosensors neurotransmitter detection.
Ashley Ross, Ph.D. (Committee Chair)
Ryan White (Committee Member)
Noe Alvarez, Ph.D. (Committee Member)
200 p.
Chemistry
Fast scan cyclic voltammetry; Carbon fiber Microelectrode; Neurotransmitter detection; Graphene; metal nanoparticles

Recommended Citations

Citations

  • Li, Y. (2021). Novel Microelectrodes and New Material for Real-Time Electrochemical Detection of Neurotransmitters [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin163715413634062

    APA Style (7th edition)

  • Li, Yuxin. Novel Microelectrodes and New Material for Real-Time Electrochemical Detection of Neurotransmitters. 2021. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin163715413634062.

    MLA Style (8th edition)

  • Li, Yuxin. "Novel Microelectrodes and New Material for Real-Time Electrochemical Detection of Neurotransmitters." Doctoral dissertation, University of Cincinnati, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin163715413634062

    Chicago Manual of Style (17th edition)

ucin163715413634062
42
© 2021, some rights reserved.Creative Commons License Novel Microelectrodes and New Material for Real-Time Electrochemical Detection of Neurotransmitters by Yuxin Li is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by University of Cincinnati and OhioLINK.