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Full text release has been delayed at the author's request until September 30, 2025
ETD Abstract Container
Abstract Header
Transcriptional Regulatory Mechanisms for Robust Somite Segmentation
Author Info
Zinani, Oriana Q.H.
ORCID® Identifier
http://orcid.org/0000-0002-3939-3708
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1623169652452311
Abstract Details
Year and Degree
2021, PhD, University of Cincinnati, Medicine: Molecular and Developmental Biology.
Abstract
Gene-pairs represent at least 50% of E.coli and 10% of human genes. The gene pairing phenomenon is likely to have appeared during genome gene-duplication events. However, it is not entirely understood whether there is an evolutionary advantage of gene pairing. We do not have clear evidence to differentiate between the following scenarios: Is gene pairing simply a side effect of gene duplication or does gene paring ensure robust outcomes during embryonic development? In my thesis, I will discuss how gene-pairing can lead to co-expression of genes. For fast dynamic systems, such as somitogenesis, co-expression of regulatory genes results in robust pattern formation, increasing overall fitness of species.
Committee
Ertugrul Ozbudak, Ph.D. (Committee Chair)
Brian Gebelein, Ph.D. (Committee Member)
Christian Hong, Ph.D. (Committee Member)
Raphael Kopan, Ph.D. (Committee Member)
Tongli Zhang, Ph.D. (Committee Member)
Pages
149 p.
Subject Headings
Developmental Biology
Keywords
Gene expression noise
;
Zebrafish
;
Math Modeling
;
CRISPR
;
Segmentation clock
;
Notch signaling
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Citations
Zinani, O. Q.H. (2021).
Transcriptional Regulatory Mechanisms for Robust Somite Segmentation
[Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1623169652452311
APA Style (7th edition)
Zinani, Oriana.
Transcriptional Regulatory Mechanisms for Robust Somite Segmentation.
2021. University of Cincinnati, Doctoral dissertation.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1623169652452311.
MLA Style (8th edition)
Zinani, Oriana. "Transcriptional Regulatory Mechanisms for Robust Somite Segmentation." Doctoral dissertation, University of Cincinnati, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1623169652452311
Chicago Manual of Style (17th edition)
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Document number:
ucin1623169652452311
Copyright Info
© 2021, some rights reserved.
Transcriptional Regulatory Mechanisms for Robust Somite Segmentation by Oriana Q.H. Zinani is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by University of Cincinnati and OhioLINK.