Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


38034.pdf (1.19 MB)

ETD Abstract Container

Abstract Header

Seizures and Cognitive Outcome after Traumatic Brain Injury

Foreman, Brandon
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1613740950460712

Abstract Details

2020, MS, University of Cincinnati, Medicine: Clinical and Translational Research.
Objective: Seizures and abnormal periodic or rhythmic patterns are observed on continuous electroencephalography (cEEG) in up to half of patients hospitalized with moderate-to-severe traumatic brain injury (TBI). We aimed to determine the impact of seizures and abnormal periodic or rhythmic patterns on cognitive outcome 3 months following moderate-to-severe TBI. Design: Post-hoc analysis of a multicenter randomized, controlled phase 2 clinical trial conducted from 2010-2016 across 20 US Level I trauma centers. Patients with non-penetrating TBI and post-resuscitation Glasgow Coma Scale (GCS) 4–12 were included. Bedside cEEG was initiated per protocol upon admission to intensive care and the burden of ictal-interictal continuum (IIC) patterns including seizures was quantified. A summary global cognition score at 3 months following injury was used as the primary outcome. Measures and Main Results: 142 patients (age mean+/-SD 32+/-13 years; 131 [92%] male) survived with a mean global cognition score of 81+/-15; nearly one-third were considered to have poor functional outcome. 89/142 (63%) patients underwent cEEG, of whom 13/89 (15%) had severe IIC patterns. The quantitative burden of IIC patterns correlated inversely with the global cognition score (r=-0.57; p=0.04). In multiple variable analysis, the burden of IIC patterns was independently associated with the global cognition score after controlling for demographics, pre-morbid estimated intelligence, injury severity, sedatives and antiseizure drugs. Conclusions: The burden of seizures and abnormal periodic or rhythmic patterns was independently associated with worse cognition at 3 months following TBI. Their impact on longer-term cognitive endpoints and the potential benefits of seizure detection and treatment in this population warrant prospective study.
Scott Langevin, Ph.D. (Committee Chair)
Daniel Woo, M.D. (Committee Member)
Nanhua Zhang, Ph.D. (Committee Member)
34 p.
Surgery
Traumatic Brain Injury; Seizures; Neurocritical Care; Neurotrauma; Cognitive Outcomes; EEG

Recommended Citations

Citations

  • Foreman, B. (2020). Seizures and Cognitive Outcome after Traumatic Brain Injury [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1613740950460712

    APA Style (7th edition)

  • Foreman, Brandon. Seizures and Cognitive Outcome after Traumatic Brain Injury. 2020. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1613740950460712.

    MLA Style (8th edition)

  • Foreman, Brandon. "Seizures and Cognitive Outcome after Traumatic Brain Injury." Master's thesis, University of Cincinnati, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1613740950460712

    Chicago Manual of Style (17th edition)

ucin1613740950460712
79
© 2020, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.