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Single-cell transcriptomic analysis of vascular progenitors and the roles of Vegf signaling and Ets1 in vascular development

Casie Chetty, David S
http://orcid.org/0000-0002-7179-9687
http://rave.ohiolink.edu/etdc/view?acc_num=ucin159326667315738

Abstract Details

2020, PhD, University of Cincinnati, Medicine: Molecular and Developmental Biology.
The formation of a functional vascular system is required for proper embryonic development in all vertebrates. Being one of the first organ systems to form during embryogenesis, ¬the cardiovascular system, comprising the heart, arteries, veins and capillaries, transports nutrients, oxygen, metabolites, waste, immune cells and hormones throughout the body. Thus, the formation of organ systems during development and subsequent maintenance throughout life is reliant upon a normal functional vascular system. This dissertation focuses on the molecular mechanisms that govern vascular development in zebrafish embryos. We utilize zebrafish embryos due to their rapid development, optical transparency and high amenability to genetic manipulation.
Saulius Sumanas, Ph.D. (Committee Chair)
Elisa Boscolo, Ph.D. (Committee Member)
Brian Gebelein, Ph.D. (Committee Member)
Joshua Waxman, Ph.D. (Committee Member)
Katherine Yutzey, Ph.D. (Committee Member)
256 p.
Cognitive Psychology; Developmental Biology
Vasculogenesis; Development; ETS factors; Angiogenesis; Etv2; VEGF

Recommended Citations

Citations

  • Casie Chetty, D. S. (2020). Single-cell transcriptomic analysis of vascular progenitors and the roles of Vegf signaling and Ets1 in vascular development [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin159326667315738

    APA Style (7th edition)

  • Casie Chetty, David. Single-cell transcriptomic analysis of vascular progenitors and the roles of Vegf signaling and Ets1 in vascular development. 2020. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin159326667315738.

    MLA Style (8th edition)

  • Casie Chetty, David. "Single-cell transcriptomic analysis of vascular progenitors and the roles of Vegf signaling and Ets1 in vascular development." Doctoral dissertation, University of Cincinnati, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin159326667315738

    Chicago Manual of Style (17th edition)

ucin159326667315738
83
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This open access ETD is published by University of Cincinnati and OhioLINK.