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Investigation of a Method for Predicting Immediately Dangerous to Life and Health (IDLH) Values Using Inhalation Irritation Data

Parker, Ann L
http://orcid.org/0000-0003-1660-9710
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1575967182012512

Abstract Details

2019, MS, University of Cincinnati, Medicine: Industrial Hygiene (Environmental Health).
Immediately Dangerous to Life and Health (IDLH) values, developed by National Institute for Occupational Safety and Health (NIOSH), are 30-minute exposure values to protect workers from irreversible health effects, escape impairing effects, and death during an emergency. Developing an IDLH is a long process which is why there are approximately 135 IDLH values for the thousands of chemicals in commerce. The occupational community would benefit from developing additional IDLHs. Previous research has shown that a respiratory rate decrease of 50% (RD50) in animal studies has a good correlation with occupational exposure limits (OELs) (Alarie, 1981). This paper investigates extending the concept to escape impairing effects by using 30-minute Acute Exposure Guideline Levels (AEGLs) in a linear regression analysis with RD50 values. The 30-minute AEGL2 was used because the methodology, health effects, and duration are similar to IDLH values, thus are expected to comparable. The regression analysis of RD50 and AEGL2 was explored to determine if the values were correlated and if the resulting equation could be used in an algorithm along with the relationship between AEGL2 and IDLH to accurately predict an IDLH from a RD50 value. The regression analysis showed good correlation with a r2 of 0.74 for the RD50 and AEGL2 relationship and a r2 of 0.84 for the RD50 and IDLH relationship. The closeness of the correlations indicates that it may not be necessary to use the AEGL2 as a surrogate for the IDLH in a prediction algorithm for an IDLH. The next step is to validate the model with data separate from the data used to develop the model.
John Reichard, PharmD Ph.D. (Committee Chair)
Jurate Virkutyte, Ph.D. (Committee Member)
25 p.
Occupational Safety
Immediately Dangerous to Life and Health; IDLH; respiratory rate decrease; RD50; sensory irritation; regression analysis

Recommended Citations

Citations

  • Parker, A. L. (2019). Investigation of a Method for Predicting Immediately Dangerous to Life and Health (IDLH) Values Using Inhalation Irritation Data [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1575967182012512

    APA Style (7th edition)

  • Parker, Ann. Investigation of a Method for Predicting Immediately Dangerous to Life and Health (IDLH) Values Using Inhalation Irritation Data. 2019. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1575967182012512.

    MLA Style (8th edition)

  • Parker, Ann. "Investigation of a Method for Predicting Immediately Dangerous to Life and Health (IDLH) Values Using Inhalation Irritation Data." Master's thesis, University of Cincinnati, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1575967182012512

    Chicago Manual of Style (17th edition)

ucin1575967182012512
197
© 2019, some rights reserved.Creative Commons License Investigation of a Method for Predicting Immediately Dangerous to Life and Health (IDLH) Values Using Inhalation Irritation Data by Ann L Parker is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by University of Cincinnati and OhioLINK.