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Mechanisms of anionic surfactant penetration into human skin
Author Info
Ventura, Stephanie A
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1553251546272157
Abstract Details
Year and Degree
2019, PhD, University of Cincinnati, Pharmacy: Pharmaceutical Sciences/Biopharmaceutics.
Abstract
Rinse-off products are designed to cleanse the skin and hair of dirt, sweat, and oils, and then be rinsed away with water. Anionic surfactants, which are often used in rinse-off products due to their excellent foaming and lather characteristics, bind to and denature skin proteins as well as intercalate into and extract skin lipids. Repeated use leads to skin dryness and irritation over time. Although a number of theories have been proposed, the exact mechanisms of surfactant penetration into human skin remain unknown. The purpose of this research was to elucidate these mechanisms in single and mixed anionic surfactant systems. These understandings will lead to strategies which can be used to mitigate skin dryness and irritation from repeated use of commercial rinse-off products, thereby improving consumer experience and streamlining product research and development.
Committee
Gerald Kasting, Ph.D. (Committee Chair)
Kavssery Ananthapadmanabhan (Committee Member)
Thomas Beck, Ph.D. (Committee Member)
Harshita Kumari (Committee Member)
Kevin Li, Ph.D. (Committee Member)
Peng Zhang, Ph.D. (Committee Member)
Pages
197 p.
Subject Headings
Individual and Family Studies
;
Pharmaceuticals
;
Web Studies
Keywords
surfactant
;
skin penetration
;
skin barrier
;
stratum corneum
;
skin dryness
;
micelle
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Citations
Ventura, S. A. (2019).
Mechanisms of anionic surfactant penetration into human skin
[Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1553251546272157
APA Style (7th edition)
Ventura, Stephanie.
Mechanisms of anionic surfactant penetration into human skin.
2019. University of Cincinnati, Doctoral dissertation.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1553251546272157.
MLA Style (8th edition)
Ventura, Stephanie. "Mechanisms of anionic surfactant penetration into human skin." Doctoral dissertation, University of Cincinnati, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1553251546272157
Chicago Manual of Style (17th edition)
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Document number:
ucin1553251546272157
Download Count:
1,060
Copyright Info
© 2019, some rights reserved.
Mechanisms of anionic surfactant penetration into human skin by Stephanie A Ventura is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by University of Cincinnati and OhioLINK.